Comparison · NCT01967225-sae
Tedizolid Phosphate (Sivextro, BAY1192631) vs Linezolid: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Tedizolid Phosphate (Sivextro, BAY1192631) vs Linezolid: serious adverse events. Trial comparisons, record NCT01967225-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01967225-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0843 | 0.0415 | 0.164 | wilson | |
| Risk in group 2 | 0.0976 | 0.0386 | 0.225 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0132 | -0.148 | 0.0859 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.864 | 0.268 | 2.79 | log | |
| Odds ratio, group 1 over group 2 | 0.852 | 0.235 | 3.09 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Tedizolid Phosphate (Sivextro, BAY1192631) than on Linezolid | 75.6 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Tedizolid Phosphate (Sivextro, BAY1192631) | Participants received 200 mg BAY1192631 solution or tablet once daily (intravenous (I.V.) or oral (PO)) | 7 | 83 | EG000 |
| Group 2 | Linezolid | Participants received 600 mg Linezolid solution or tablet twice daily, every 12 +- 3 hours (intravenous (I.V.) or oral (PO)) | 4 | 41 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- 25 days after the last study medication administration
Source ClinicalTrials.gov
Trial
- Title
- Safety and Efficacy of BAY1192631 in Japanese Patients With Methicillin-resistant Staphylococcus Aureus (MRSA) Infections
- NCT number
- NCT01967225
- Phases
- PHASE3
- Conditions
- Skin Diseases, Infectious
- Interventions
- Tedizolid Phosphate (Sivextro, BAY1192631), Linezolid
- Lead sponsor
- Bayer
- Results first posted
- 2018-10-04
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01967225?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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