Comparison · NCT01968317-4bb89284
Megestrol Acetate and Metformin vs Megestrol Acetate: Cumulative CR Rates Within 32 Weeks
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Megestrol Acetate and Metformin vs Megestrol Acetate: Cumulative CR Rates Within 32 Weeks. Trial comparisons, record NCT01968317-4bb89284. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT01968317-4bb89284
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.743 | 0.63 | 0.831 | wilson | |
| Risk in group 2 | 0.682 | 0.562 | 0.782 | wilson | |
| Risk difference, group 1 minus group 2 | 0.061 | -0.0897 | 0.21 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.09 | 0.879 | 1.35 | log | |
| Odds ratio, group 1 over group 2 | 1.35 | 0.64 | 2.84 | log | |
| Number needed to treat, for one more participant with the outcome on Megestrol Acetate and Metformin than on Megestrol Acetate | 16.4 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Megestrol Acetate and Metformin | Patients will receive metformin 500 mg by mouth three times daily and megestrol acetate 160 mg by mouth daily. Hysteroscopic evaluation was performed every 3 months during the therapy to evaluate the endometrial condition, and the findings will be recorded. | 52 | 70 | OG000 |
| Group 2 | Megestrol Acetate | Patients will receive megestrol acetate 160 mg by mouth daily. Hysteroscopic evaluation was performed every 3 months during the therapy to evaluate the endometrial condition, and the findings will be recorded. | 45 | 66 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Cumulative CR Rates Within 32 Weeks
- Description
One of the secondary objectives was between-group comparisons of the cumulative CR rate at 6 months treatment. However, for patients who eventually underwent the second hysteroscopies for endometrium evaluation within 32 weeks of the treatment, the cumulative CR rates within 32 weeks (32w-CR rates) were analysed as secondary end point instead of the CR rate at 6 months.
- Time frame
- 32 weeks after initial treatment
- Population
In MA+metformin group, 6 cases were excluded in this analysis for 3 asking for surgery and 3 missing hysteroscopic evaluation.~In MA group, 8 cases were excluded for 2 asking for surgery and 6 missing hysteroscopic evaluation.
Source ClinicalTrials.gov
Trial
- Title
- Megestrol Acetate Plus Metformin to Megestrol Acetate in Patients With Endometrial Atypical Hyperplasia or Early Stage Endometrial Adenocarcinoma
- NCT number
- NCT01968317
- Phases
- PHASE2
- Conditions
- Endometrial Atypical Hyperplasia, Endometrial Adenocarcinoma
- Interventions
- Megestrol acetate and metformin, Megestrol acetate
- Lead sponsor
- Xiaojun Chen
- Results first posted
- 2021-09-13
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT01968317?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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