Comparison · NCT02020889-3dbde66e
Mepolizumab 300mg vs Placebo: Number of Participants Who Are in Remission at 36 and 48 Weeks
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Mepolizumab 300mg vs Placebo: Number of Participants Who Are in Remission at 36 and 48 Weeks. Trial comparisons, record NCT02020889-3dbde66e. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02020889-3dbde66e
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.412 | 0.303 | 0.53 | wilson | |
| Risk in group 2 | 0.103 | 0.0508 | 0.198 | wilson | |
| Risk difference, group 1 minus group 2 | 0.309 | 0.164 | 0.438 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 4 | 1.88 | 8.53 | log | |
| Odds ratio, group 1 over group 2 | 6.1 | 2.43 | 15.3 | log | |
| Number needed to treat, for one more participant with the outcome on Mepolizumab 300mg than on Placebo | 3.24 | 2.28 | 6.09 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Mepolizumab 300mg | Participants received Mepolizumab 300mg injection via SC route once every 4 weeks along with SOC drugs up to Week 48. | 28 | 68 | OG001 |
| Group 2 | Placebo | Participants received placebo injection via subcutaneous (SC) route once every 4 weeks along with standard of care (SOC) drugs up to Week 48. | 7 | 68 | OG000 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants Who Are in Remission at 36 and 48 Weeks
- Description
The number of participants who were in remission (i.e ., BVAS=0 and prednisolone /prednisone \<=7.5mg/day) at both Weeks 36 and 48 of the study treatment period was reported. The statistical analysis was performed using a logistic regression model on ITT Population. The odds ratio for treatment difference and associated p-value and 95 percent CI were calculated.
- Time frame
- Week 36 and Week 48
- Population
- ITT Population
Source ClinicalTrials.gov
Trial
- Title
- A Study to Investigate Mepolizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis
- NCT number
- NCT02020889
- Phases
- PHASE3
- Conditions
- Churg-Strauss Syndrome
- Interventions
- Mepolizumab, Placebo
- Lead sponsor
- GlaxoSmithKline
- Results first posted
- 2018-01-26
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02020889?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT02020889-3dbde66e