Comparison · NCT02021929-9fbcf416
Sorafenib vs Placebo: Number of Participants With Improvement in Intrapulmonary Shunting From Baseline to 12 Weeks.
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Sorafenib vs Placebo: Number of Participants With Improvement in Intrapulmonary Shunting From Baseline to 12 Weeks. Trial comparisons, record NCT02021929-9fbcf416. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02021929-9fbcf416
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.25 | 0.0889 | 0.532 | wilson | |
| Risk in group 2 | 0.667 | 0.354 | 0.879 | wilson | |
| Risk difference, group 1 minus group 2 | -0.417 | -0.684 | 0.00444 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.375 | 0.127 | 1.11 | log | |
| Odds ratio, group 1 over group 2 | 0.167 | 0.0248 | 1.12 | log | |
| Number needed to treat, for one fewer participant with the outcome on Sorafenib than on Placebo | 2.4 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Sorafenib | 400 mg (2 capsules) taken by mouth once a day~Sorafenib: Sorafenib is a kinase inhibitor indicated for the treatment of:~* Unresectable hepatocellular carcinoma~* Advanced renal cell carcinoma~* Locally recurrent or metastatic, progressive, differentiated thyroid carcinoma refractory to radioactive iodine treatment | 3 | 12 | OG000 |
| Group 2 | Placebo | 2 capsules taken by mouth once a day~Placebo | 6 | 9 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Improvement in Intrapulmonary Shunting From Baseline to 12 Weeks.
- Description
Intrapulmonary shunting is measured based on results from a saline-bubble echo test.~Number of participants with measured improvement in intrapulmonary shunting from baseline to 12 weeks in the sorafenib and placebo groups
- Time frame
- Baseline to 12 weeks
- Population
- Since all of the participants did not complete the 12 week study visit, data from fewer participants were available to be analyzed in each arm for this measure.
Source ClinicalTrials.gov
Trial
- Title
- Sorafenib for Hepatopulmonary Syndrome
- NCT number
- NCT02021929
- Phases
- PHASE2
- Conditions
- Hepatopulmonary Syndrome
- Interventions
- Sorafenib, Placebo
- Lead sponsor
- University of Pennsylvania
- Results first posted
- 2019-04-25
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02021929?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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