Comparison · NCT02028676-a1decff9
Continued Cotrimoxazole Prophylaxis vs Stopped Cotrimoxazole Prophylaxis: Cotrimoxazole: All-cause Mortality
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Continued Cotrimoxazole Prophylaxis vs Stopped Cotrimoxazole Prophylaxis: Cotrimoxazole: All-cause Mortality. Trial comparisons, record NCT02028676-a1decff9. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02028676-a1decff9
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.00798 | 0.00272 | 0.0232 | wilson | |
| Risk in group 2 | 0.00524 | 0.00144 | 0.0189 | wilson | |
| Risk difference, group 1 minus group 2 | 0.00274 | -0.0119 | 0.0184 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.52 | 0.256 | 9.07 | log | |
| Odds ratio, group 1 over group 2 | 1.53 | 0.254 | 9.2 | log | |
| Number needed to treat, for one more participant with the outcome on Continued Cotrimoxazole Prophylaxis than on Stopped Cotrimoxazole Prophylaxis | 365 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Continued Cotrimoxazole Prophylaxis | Other Names:~trimethoprim+sulfamethoxazole | 3 | 376 | OG000 |
| Group 2 | Stopped Cotrimoxazole Prophylaxis | 2 | 382 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Cotrimoxazole: All-cause Mortality
- Description
- Number of participants who died, to be analysed using time-to-event methods
- Time frame
- Median 2 years (from cotrimoxazole randomization to 16 March 2012; maximum 2.5 years)
- Population
Source ClinicalTrials.gov
Trial
- Title
- Efficacy Study of Different Laboratory Management Strategies and Drug Regimens in HIV-infected Children in Africa
- NCT number
- NCT02028676
- Phases
- PHASE4
- Conditions
- Human Immunodeficiency Virus
- Interventions
Clinically Driven Monitoring (CDM), Laboratory plus Clinical Monitoring (LCM), Arm A: ABC+3TC+NNRTI, Arm B: ZDV+ABC+3TC+NNRTI->ABC+3TC+NNRTI maintenance, Arm C: ZDV+ABC+3TC+NNRTI->ZDV+ABC+3TC maintenance, Once-daily ABC+3TC, Twice-daily ABC+3TC, Continued cotrimoxazole prophylaxis, Stopped cotrimoxazole prophylaxis
- Lead sponsor
- Medical Research Council
- Results first posted
- 2014-06-06
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02028676?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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