Comparison · NCT02130986-adb770fb
Procalcitonin (PCT) Group vs Usual Care Group: Antibiotic Prescription in Emergency Department(ED)
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Procalcitonin (PCT) Group vs Usual Care Group: Antibiotic Prescription in Emergency Department(ED). Trial comparisons, record NCT02130986-adb770fb. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02130986-adb770fb
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.341 | 0.31 | 0.374 | wilson | |
| Risk in group 2 | 0.387 | 0.354 | 0.42 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0453 | -0.0914 | 0.001 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.883 | 0.777 | 1 | log | |
| Odds ratio, group 1 over group 2 | 0.822 | 0.673 | 1 | log | |
| Number needed to treat, for one fewer participant with the outcome on Procalcitonin (PCT) Group than on Usual Care Group | 22.1 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: usual care.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Procalcitonin (PCT) Group | Procalcitonin (PCT) level; Results of procalcitonin level to treating clinician; Provide procalcitonin guideline to treating clinician; Telephone Visit at Day 15 and Day 30~Procalcitonin level: A procalcitonin (PCT) will be drawn level within one hour after randomization in the ED, and if hospitalized, 6-24 hours after the initial ED blood draw, and on Days 3, 5, and 7. Days 3, 5, and 7 blood draws for procalcitonin will only occur in hospitalized patients on antibiotics and/or at the treating physician's discretion.~Results of procalcitonin (PCT) level to treating clinician: In the ED, we will quickly (\<1 hour goal) provide clinicians the procalcitonin result.~Provide procalcitonin guideline to treating clinician: Procalcitonin antibiotic guideline --~Procalcitonin level (ug/L) -- Bacterial etiology -- Recommendation \< 0.1 -- Very unlikely -- Antibiotics strongly discouraged(1) 0.1 - 0.25 -- Unlikely -- Antibiotics discouraged(1 | 282 | 826 | OG000 |
| Group 2 | Usual Care Group | Telephone Visit at Day 15 and Day 30~Telephone Visit: We will collect the number of antibiotic days during telephone visits occurring on or around Day 15 and Day 30 | 321 | 830 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Antibiotic Prescription in Emergency Department(ED)
- Description
- Antibiotic prescription in the ED includes post-randomization receipt of antibiotics in ED and provision of an antibiotic prescription for patients at the time of discharge from the ED.
- Time frame
- While in the ED or before ED discharge (majority patients < 1 day)
- Population
Source ClinicalTrials.gov
Trial
- Title
- Procalcitonin Antibiotic Consensus Trial (ProACT)
- NCT number
- NCT02130986
- Phases
- NA
- Conditions
- Lower Respiratory Tract Infection (LRTI)
- Interventions
- Procalcitonin level, Results of procalcitonin (PCT) level to treating clinician, Provide procalcitonin guideline to treating clinician, Telephone Visit
- Lead sponsor
- University of Pittsburgh
- Results first posted
- 2019-01-15
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02130986?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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