Comparison · NCT02145468-495f8dfb
Losmapimod 7.5 mg BID vs Placebo: Number of Participants Re-hospitalized Within 30 Days of Discharge
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Losmapimod 7.5 mg BID vs Placebo: Number of Participants Re-hospitalized Within 30 Days of Discharge. Trial comparisons, record NCT02145468-495f8dfb. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02145468-495f8dfb
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.123 | 0.108 | 0.139 | wilson | |
| Risk in group 2 | 0.119 | 0.105 | 0.135 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0036 | -0.0181 | 0.0253 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.03 | 0.862 | 1.23 | log | |
| Odds ratio, group 1 over group 2 | 1.03 | 0.844 | 1.27 | log | |
| Number needed to treat, for one more participant with the outcome on Losmapimod 7.5 mg BID than on Placebo | 278 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Losmapimod 7.5 mg BID | Participants received losmapimod 7.5 mg tablets via oral route, BID, according to the randomization schedule for 12 weeks in addition to standard of care, and were followed for an additional 12 weeks after completing treatment, for a total study duration of 24 weeks. | 213 | 1,731 | OG001 |
| Group 2 | Placebo | Participants received losmapimod matching placebo tablets via oral route, BID, according to the randomization schedule for 12 weeks in addition to standard of care, and were followed for an additional 12 weeks after completing treatment, for a total study duration of 24 weeks. | 210 | 1,758 | OG000 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants Re-hospitalized Within 30 Days of Discharge
- Description
- Participants who had a death or re-hospitalization within 30 days of discharge, plus participants who were never discharged from the initial hospitalization were included.
- Time frame
- Within up to 30 days of post discharge
- Population
- ITT Population
Source ClinicalTrials.gov
Trial
- Title
A Phase 3 Clinical Outcomes Study to Compare the Incidence of Major Adverse Cardiovascular Events in Subjects Presenting With Acute Coronary Syndrome Treated With Losmapimod Compared to Placebo (LATITUDE-TIMI 60)
- NCT number
- NCT02145468
- Phases
- PHASE3
- Conditions
- Acute Coronary Syndrome
- Interventions
- Losmapimod 7.5 mg twice daily, Placebo twice daily, Standard therapy
- Lead sponsor
- GlaxoSmithKline
- Results first posted
- 2017-06-02
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02145468?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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