Comparison · NCT02148705-d3391508
NexoBrid Gel vs Gel Vehicle: Primary Endpoint: Number of Participants With Complete Eschar Removal.
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. NexoBrid Gel vs Gel Vehicle: Primary Endpoint: Number of Participants With Complete Eschar Removal. Trial comparisons, record NCT02148705-d3391508. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02148705-d3391508
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.933 | 0.853 | 0.971 | wilson | |
| Risk in group 2 | 0.04 | 0.0071 | 0.195 | wilson | |
| Risk difference, group 1 minus group 2 | 0.893 | 0.718 | 0.943 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 23.3 | 3.42 | 159 | log | |
| Odds ratio, group 1 over group 2 | 336 | 37.4 | 3,020 | log | |
| Number needed to treat, for one more participant with the outcome on NexoBrid Gel than on Gel Vehicle | 1.12 | 1.06 | 1.39 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: vehicle.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | NexoBrid Gel | NexoBrid Gel is applied to the burn wound at a dose of 2 g NexoBrid sterile powder mixed with 20g sterile Gel Vehicle per 1% of TBSA (\~ surface of an adult palm) for four hours.~NexoBrid | 70 | 75 | OG000 |
| Group 2 | Gel Vehicle | Gel Vehicle is applied to the burn wound at a dose of 20 g sterile Gel per 1% of TBSA (\~ surface of an adult palm) for four hours.~Gel Vehicle | 1 | 25 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Primary Endpoint: Number of Participants With Complete Eschar Removal.
- Description
- Comparison of NexoBrid over Gel Vehicle for eschar removal as measured by Number of Participants with complete eschar removal at the end of the topical agent soaking period by a blinded assessor.
- Time frame
- post application (post 2 h soaking)
- Population
- Standard of Care (SOC) is not included as it was pre-specified in the statistical analysis plan that for the primary endpoint, NexoBrid Gel will be compared only to the Gel Vehicle
Source ClinicalTrials.gov
Trial
- Title
- A Study to Evaluate the Efficacy and Safety of NexoBrid in Subjects With Thermal Burns
- NCT number
- NCT02148705
- Phases
- PHASE3
- Conditions
- Thermal Burns
- Interventions
- NexoBrid, Standard of Care (SOC), Gel Vehicle
- Lead sponsor
- MediWound Ltd
- Results first posted
- 2023-06-27
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02148705?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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