Comparison · NCT02163499-sae
Acute Phase: ZS vs Extended Dosing Phase: ZS: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Acute Phase: ZS vs Extended Dosing Phase: ZS: serious adverse events. Trial comparisons, record NCT02163499-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02163499-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.00133 | 0.000235 | 0.0075 | wilson | |
| Risk in group 2 | 0.216 | 0.188 | 0.247 | wilson | |
| Risk difference, group 1 minus group 2 | -0.214 | -0.245 | -0.186 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.00617 | 0.000866 | 0.044 | log | |
| Odds ratio, group 1 over group 2 | 0.00484 | 0.000676 | 0.0347 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Acute Phase: ZS than on Extended Dosing Phase: ZS | 4.66 | 4.07 | 5.38 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Acute Phase: ZS | 1 | 751 | EG000 | |
| Group 2 | Extended Dosing Phase: ZS | 161 | 746 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- One year
Source ClinicalTrials.gov
Trial
- Title
- Open-label Safety and Efficacy of Sodium Zirconium Cyclosilicate for up to 12 Months
- NCT number
- NCT02163499
- Phases
- PHASE3
- Conditions
- Hyperkalemia
- Interventions
- Sodium Zirconium Cyclosilicate
- Lead sponsor
- ZS Pharma, Inc.
- Results first posted
- 2018-06-27
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02163499?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
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GET https://conductscience.org/api/comparisons/v1/NCT02163499-sae