Comparison · NCT02180659-sae
Buprenorphine Implants + Placebo Tablets vs Buprenorphine Tablets + Placebo Implants: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Buprenorphine Implants + Placebo Tablets vs Buprenorphine Tablets + Placebo Implants: serious adverse events. Trial comparisons, record NCT02180659-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02180659-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.023 | 0.00633 | 0.08 | wilson | |
| Risk in group 2 | 0.0337 | 0.0115 | 0.0945 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0107 | -0.0737 | 0.0504 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.682 | 0.117 | 3.98 | log | |
| Odds ratio, group 1 over group 2 | 0.675 | 0.11 | 4.14 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Buprenorphine Implants + Placebo Tablets than on Buprenorphine Tablets + Placebo Implants | 93.3 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Buprenorphine Implants + Placebo Tablets | Four 80 mg Probuphine implants + daily SL placebo tablets~Buprenorphine implant~sublingual placebo tablets | 2 | 87 | EG000 |
| Group 2 | Buprenorphine Tablets + Placebo Implants | Daily SL BPN tablets (≤8 mg/daily) + four placebo implants~sublingual buprenorphine tablets~placebo implants | 3 | 89 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
All AEs were documented and followed from the time the subject signed the ICF until 14 days after the EOT Visit (i.e., implant removal and discontinuation of SL BPN/placebo treatment) which was approximately 28 weeks. Serious adverse events and AEs designated as possibly related to study drug were followed until resolution or stabilization.
Source ClinicalTrials.gov
Trial
- Title
- A Study of Adult Outpatients With Opioid Dependence Transitioned From a Daily SL Buprenorphine to Probuphine® Subdermal Implants
- NCT number
- NCT02180659
- Phases
- PHASE3
- Conditions
- Opioid Dependence
- Interventions
- sublingual buprenorphine tablets, Buprenorphine implant, placebo implants, sublingual placebo tablets
- Lead sponsor
- Titan Pharmaceuticals
- Results first posted
- 2018-12-05
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02180659?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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