Comparison · NCT02205359-776bac53
aCRT ON vs aCRT OFF: All-cause Mortality
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. aCRT ON vs aCRT OFF: All-cause Mortality. Trial comparisons, record NCT02205359-776bac53. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02205359-776bac53
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.162 | 0.146 | 0.18 | wilson | |
| Risk in group 2 | 0.181 | 0.164 | 0.199 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0191 | -0.0436 | 0.00549 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.895 | 0.775 | 1.03 | log | |
| Odds ratio, group 1 over group 2 | 0.874 | 0.735 | 1.04 | log | |
| Number needed to treat, for one fewer participant with the outcome on aCRT ON than on aCRT OFF | 52.4 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | aCRT ON | The aCRT algorithm has been developed to provide RV-synchronized LV pacing when intrinsic AV conduction is normal or BiV pacing otherwise~aCRT ON: CRT device with AdaptivCRT enabled (AdaptivBiV and LV) | 293 | 1,810 | OG000 |
| Group 2 | aCRT OFF | Standard CRT~aCRT OFF: CRT device with AdaptivCRT disabled | 327 | 1,807 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- All-cause Mortality
- Description
- All-cause mortality in the aCRT ON group vs the aCRT OFF group
- Time frame
- from subject randomization until the occurrence of death, median follow-up 4.9 years (max. follow-up 8.1 years)
- Population
- All randomized subjects
Source ClinicalTrials.gov
Trial
- Title
- AdaptResponse Clinical Trial
- NCT number
- NCT02205359
- Phases
- NA
- Conditions
- Heart Failure With Left Bundle Branch Block
- Interventions
- aCRT ON, aCRT OFF
- Lead sponsor
- Medtronic Cardiac Rhythm and Heart Failure
- Results first posted
- 2023-11-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02205359?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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