Comparison · NCT02224157-f9de6bf3
Placebo Bid + Symbicort 'as Needed' (Experimental) vs Pulmicort Bid + Terbutaline 'as Needed' (Active Comparator): Number of Participants Experiencing at Least One Severe Asthma Exacerbation
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Placebo Bid + Symbicort 'as Needed' (Experimental) vs Pulmicort Bid + Terbutaline 'as Needed' (Active Comparator): Number of Participants Experiencing at Least One Severe Asthma Exacerbation. Trial comparisons, record NCT02224157-f9de6bf3. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02224157-f9de6bf3
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0847 | 0.0735 | 0.0974 | wilson | |
| Risk in group 2 | 0.0882 | 0.0767 | 0.101 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00344 | -0.0205 | 0.0137 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.961 | 0.789 | 1.17 | log | |
| Odds ratio, group 1 over group 2 | 0.957 | 0.772 | 1.19 | log | |
| Number needed to treat, for one fewer participant with the outcome on Placebo Bid + Symbicort 'as Needed' (Experimental) than on Pulmicort Bid + Terbutaline 'as Needed' (Active Comparator) | 291 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Placebo Bid + Symbicort 'as Needed' (Experimental) | Placebo for budesonide (Placebo Turbuhaler) + Symbicort Turbuhaler (budesonide/formoterol 160/4.5 μg) | 177 | 2,089 | OG000 |
| Group 2 | Pulmicort Bid + Terbutaline 'as Needed' (Active Comparator) | Pulmicort Turbuhaler (budesonide 200 μg) + Terbutaline Turbuhaler 0.4mg 'as needed' | 184 | 2,087 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants Experiencing at Least One Severe Asthma Exacerbation
- Description
A severe exacerbation is defined as a deterioration of asthma requiring any of the following: use of systemic glucocorticosteroids (GCS) for at least 3 days, inpatient hospitalization, or emergency room visit due to asthma that required systemic steroids.
- Time frame
- Day 1 up to 52 weeks
- Population
- Full analysis set
Source ClinicalTrials.gov
Trial
- Title
- A Clinical Study to Evaluate Symbicort Turbuhaler Used 'as Needed' in Adults and Adolescents With Asthma
- NCT number
- NCT02224157
- Phases
- PHASE3
- Conditions
- Asthma
- Interventions
- budesonide/formoterol 'as needed' + budesonide placebo bid, budesonode bid + terbutaline 'as needed'
- Lead sponsor
- AstraZeneca
- Results first posted
- 2019-11-25
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02224157?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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