Comparison · NCT02248636-deaths
Real Discontinuation vs Sham Discontinuation: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Real Discontinuation vs Sham Discontinuation: deaths from any cause. Trial comparisons, record NCT02248636-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02248636-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0 | 0 | 0.129 | wilson | |
| Risk in group 2 | 0.0286 | 0.00506 | 0.145 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0286 | -0.145 | 0.102 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat, for one fewer death from any cause on Real Discontinuation than on Sham Discontinuation | 35 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: sham.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Real Discontinuation | This group is tapered off their previous cholinesterase inhibitor medication.~Cholinesterase inhibitor: This group receives a half-dose of their previous cholinesterase inhibitor medication (in overencapsulated form) for two weeks, then receives placebo. | 0 | 26 | EG000 |
| Group 2 | Sham Discontinuation | This group receives their previous cholinesterase inhibitor medication, but in in placebo form.~Sham discontinuation: This group receives their previous dose of cholinesterase inhibitor medication, but in overencapsulated form | 1 | 35 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- Six weeks.
Source ClinicalTrials.gov
Trial
- Title
- Cholinesterase Inhibitor Discontinuation
- NCT number
- NCT02248636
- Phases
- PHASE2, PHASE3
- Conditions
- Dementia
- Interventions
- Cholinesterase inhibitor, Sham discontinuation
- Lead sponsor
- VA Office of Research and Development
- Results first posted
- 2020-10-23
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02248636?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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