Comparison · NCT02279498-sae
Liprotamase vs Porcine (Pig) PERT: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Liprotamase vs Porcine (Pig) PERT: serious adverse events. Trial comparisons, record NCT02279498-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02279498-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.108 | 0.0532 | 0.206 | wilson | |
| Risk in group 2 | 0.0952 | 0.0444 | 0.193 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0125 | -0.0992 | 0.123 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.13 | 0.402 | 3.18 | log | |
| Odds ratio, group 1 over group 2 | 1.15 | 0.363 | 3.62 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Liprotamase than on Porcine (Pig) PERT | 80.3 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Liprotamase | Individually-optimized dose to be administered orally~Liprotamase: oral, soluble, non-enterically coated, non-porcine, pancreatic enzyme replacement | 7 | 65 | EG000 |
| Group 2 | Porcine (Pig) PERT | Individually-optimized dose to be administered orally~porcine (pig) PERT: oral, enterically-coated, pancreatic replacement enzymes prepared from a porcine source | 6 | 63 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- 6 months
Source ClinicalTrials.gov
Trial
- Title
- SOLUTION: Study of Oral Liprotamase Unit-Matched Therapy Of Non-Porcine Origin in Patients With Cystic Fibrosis
- NCT number
- NCT02279498
- Phases
- PHASE3
- Conditions
- Exocrine Pancreatic Insufficiency, Cystic Fibrosis
- Interventions
- Liprotamase, porcine (pig) PERT
- Lead sponsor
- Anthera Pharmaceuticals
- Results first posted
- 2018-08-14
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02279498?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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