Comparison · NCT02284399-c67b08c3
IDTFK Group Post NIPT - (January 2012-June 2014) vs IDTFK Group Pre-NIPT (January 2010-July 2010): Frequency of Positive Tests for Abnormal Karyotype Before and After the Adoption of NIPT Testing.
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. IDTFK Group Post NIPT - (January 2012-June 2014) vs IDTFK Group Pre-NIPT (January 2010-July 2010): Frequency of Positive Tests for Abnormal Karyotype Before and After the Adoption of NIPT Testing. Trial comparisons, record NCT02284399-c67b08c3. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02284399-c67b08c3
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.148 | 0.136 | 0.161 | wilson | |
| Risk in group 2 | 0.0736 | 0.0611 | 0.0883 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0741 | 0.055 | 0.0921 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 2.01 | 1.64 | 2.46 | log | |
| Odds ratio, group 1 over group 2 | 2.18 | 1.75 | 2.73 | log | |
| Number needed to treat, for one more participant with the outcome on IDTFK Group Post NIPT - (January 2012-June 2014) than on IDTFK Group Pre-NIPT (January 2010-July 2010) | 13.5 | 10.9 | 18.2 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | IDTFK Group Post NIPT - (January 2012-June 2014) | Number of pregnant women who present to participating centers between January 2012-June 2014, after the release of non-invasive prenatal testing (NIPT), who are undergoing invasive prenatal diagnostic testing for fetal karyotype (IDTFK).~non-invasive prenatal testing procedure: Noninvasive Prenatal Testing (NIPT) of fetal cell free DNA in maternal circulation | 454 | 3,074 | OG000 |
| Group 2 | IDTFK Group Pre-NIPT (January 2010-July 2010) | A control group of pregnant women, prior to the release of non-invasive prenatal testing (NIPT), who present to participating centers between January 2010-June 2010 and are undergoing invasive prenatal diagnostic testing for fetal karyotype (IDTFK). | 104 | 1,414 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Frequency of Positive Tests for Abnormal Karyotype Before and After the Adoption of NIPT Testing.
- Description
- Will determine if frequency of positive tests for abnormal karyotypes between the control period and the study period where different.
- Time frame
- 4 years
- Population
- The number of positive tests identified between the control and the test periods.
Source ClinicalTrials.gov
Trial
- Title
- National Prevalence and Impact of Noninvasive Prenatal Testing
- NCT number
- NCT02284399
- Phases
- Conditions
- Aneuploidy
- Interventions
- non-invasive prenatal testing
- Lead sponsor
- Obstetrix Medical Group
- Results first posted
- 2019-06-19
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02284399?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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