Comparison · NCT02297815-1abbd482
Narrow Spectrum Antibiotic vs Non-narrow Spectrum Antibiotic: Symptoms Present on Day 3
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Narrow Spectrum Antibiotic vs Non-narrow Spectrum Antibiotic: Symptoms Present on Day 3. Trial comparisons, record NCT02297815-1abbd482. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02297815-1abbd482
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.379 | 0.351 | 0.407 | wilson | |
| Risk in group 2 | 0.413 | 0.375 | 0.451 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0341 | -0.0815 | 0.0129 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.917 | 0.815 | 1.03 | log | |
| Odds ratio, group 1 over group 2 | 0.867 | 0.712 | 1.06 | log | |
| Number needed to treat, for one fewer participant with the outcome on Narrow Spectrum Antibiotic than on Non-narrow Spectrum Antibiotic | 29.3 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Narrow Spectrum Antibiotic | Children diagnosed with an ARTI and prescribed a narrow-spectrum antibiotic | 427 | 1,128 | OG000 |
| Group 2 | Non-narrow Spectrum Antibiotic | Children diagnosed with an ARTI and prescribed a non-narrow spectrum antibiotic | 267 | 647 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Symptoms Present on Day 3
- Description
During 5-10 day interview, parents were asked about symptoms related to child's illness (otitis media: fever, ear pain, decreased appetite; sinusitis: fever, face/head pain, decreased appetite; pharyngitis: throat pain, fever, decreased appetite). Parent was asked if symptoms was present at diagnosis. If yes, had the symptom resolved. If yes, when. We assessed whether symptoms present at day 3 after diagnosis.
- Time frame
- 3 days after ARTI diagnosis
- Population
- Among subjects who reported having at least one symptom at the time of diagnosis; 41 children missing race and ethnicity were excluded
Source ClinicalTrials.gov
Trial
- Title
- Comparative Effectiveness of Antibiotics for Respiratory Infections
- NCT number
- NCT02297815
- Phases
- Conditions
- Acute Otitis Media, Acute Sinusitis, Group A Streptococcal Pharyngitis
- Interventions
- Broad-spectrum antibiotics, Narrow-spectrum antibiotics
- Lead sponsor
- Children's Hospital of Philadelphia
- Results first posted
- 2017-12-08
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02297815?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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