Comparison · NCT02297815-bf5c5823
Narrow Spectrum Antibiotic vs Broad-Spectrum Antibiotic: Sleep Disturbance
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Narrow Spectrum Antibiotic vs Broad-Spectrum Antibiotic: Sleep Disturbance. Trial comparisons, record NCT02297815-bf5c5823. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02297815-bf5c5823
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.371 | 0.347 | 0.395 | wilson | |
| Risk in group 2 | 0.44 | 0.407 | 0.473 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0688 | -0.11 | -0.0281 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.843 | 0.764 | 0.931 | log | |
| Odds ratio, group 1 over group 2 | 0.751 | 0.634 | 0.89 | log | |
| Number needed to treat, for one fewer participant with the outcome on Narrow Spectrum Antibiotic than on Broad-Spectrum Antibiotic | 14.5 | 9.12 | 35.6 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Narrow Spectrum Antibiotic | Children diagnosed with an ARTI and prescribed a narrow-spectrum antibiotic | 582 | 1,570 | OG000 |
| Group 2 | Broad-Spectrum Antibiotic | Children diagnosed with an ARTI and prescribed a Broad-spectrum antibiotic | 378 | 860 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Sleep Disturbance
- Description
The PedsQL questionnaire includes one or two questions, depending on age, about sleep. For children \<24 months, parents are asked the frequency (never, almost never, sometimes, often, almost always) their child has (1) difficulty falling asleep and (2) difficulty sleeping through the night. For children ≥2 years, parents are asked the frequency their child has trouble sleeping. We categorized children as either without sleep disturbance (Never for each sleep question) or with sleep disturbance. Outcome measure shows the number of participants with sleep disturbance.
- Time frame
- Days 5-10 Interview
- Population
- 41 children missing race and ethnicity excluded; 1 child did not complete PedsQL
Source ClinicalTrials.gov
Trial
- Title
- Comparative Effectiveness of Antibiotics for Respiratory Infections
- NCT number
- NCT02297815
- Phases
- Conditions
- Acute Otitis Media, Acute Sinusitis, Group A Streptococcal Pharyngitis
- Interventions
- Broad-spectrum antibiotics, Narrow-spectrum antibiotics
- Lead sponsor
- Children's Hospital of Philadelphia
- Results first posted
- 2017-12-08
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02297815?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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