Xylitol vs Control: Number of Infants <2500 Grams
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.0894 | 0.0813 | 0.0983 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.129 | 0.12 | 0.138 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | -0.0397 | -0.0521 | -0.0272 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 0.693 | 0.615 | 0.78 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 0.663 | 0.581 | 0.756 | log | ClinicalTrials.gov | |
| Number needed to treat, for one fewer participant with the outcome on Xylitol than on Control | 25.2 | 19.2 | 36.8 | from the risk difference interval | ClinicalTrials.gov |
Groups 2
Group 2 names the comparator: control.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | Xylitol | Intervention group (twice daily xylitol gum use during pregnancy) | 385 | 4,305 | OG001 | ClinicalTrials.gov |
| Group 2 | Control | Control group (no xylitol gum exposure) | 679 | 5,260 | OG000 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | PRIMARY | ClinicalTrials.gov |
| Title | Number of Infants <2500 Grams | ClinicalTrials.gov |
| Description | This is a co-primary outcome: Measured weight at delivery to determine the rate of \<2500 gram infants. | ClinicalTrials.gov |
| Time frame | Date of delivery to 1 week postnatal | ClinicalTrials.gov |
| Population | There were 5260 of the 5520 subjects in the control group after removing 42 with an interrupted pregnancy, 20 prepregnant without information on neonatal outcomes, 137 lost to follow up, and 61 with only neonatal gestational age information.~There were 4305 of 4349 consented for enrollment in the xylitol intervention group, after removing 89 with an interrupted pregnancy, 5 prepregnant without neonatal outcomes data, 106 lost to follow up and 45 with only neonatal gestational age data. | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi | ClinicalTrials.gov |
| NCT number | NCT02333227 | ClinicalTrials.gov |
| Phases | NA | ClinicalTrials.gov |
| Conditions | Preterm Birth, Periodontal Disease, Caries, Dental | ClinicalTrials.gov |
| Interventions | Xylitol gum | ClinicalTrials.gov |
| Lead sponsor | Baylor College of Medicine | ClinicalTrials.gov |
| Results first posted | 2024-01-08 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT02333227?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.