Xylitol vs Control: Rate of Preterm Birth
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.126 | 0.117 | 0.136 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.165 | 0.155 | 0.175 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | -0.0388 | -0.0527 | -0.0247 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 0.765 | 0.693 | 0.845 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 0.731 | 0.652 | 0.82 | log | ClinicalTrials.gov | |
| Number needed to treat, for one fewer participant with the outcome on Xylitol than on Control | 25.8 | 19 | 40.5 | from the risk difference interval | ClinicalTrials.gov |
Groups 2
Group 2 names the comparator: control.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | Xylitol | Intervention group (twice daily xylitol gum use during pregnancy) | 549 | 4,349 | OG001 | ClinicalTrials.gov |
| Group 2 | Control | Control group (no xylitol gum exposure) | 878 | 5,321 | OG000 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | PRIMARY | ClinicalTrials.gov |
| Title | Rate of Preterm Birth | ClinicalTrials.gov |
| Description | This is a co-primary outcome: Measure rate of preterm birth \<37 weeks gestation, as defined by best obstetrical estimate based upon last menstrual period correlated with fundal height at entry to prenatal care or ultrasound, when available; all sites have access to referral for ultrasound. | ClinicalTrials.gov |
| Time frame | Conception to date of delivery, <37 weeks gestation | ClinicalTrials.gov |
| Population | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi | ClinicalTrials.gov |
| NCT number | NCT02333227 | ClinicalTrials.gov |
| Phases | NA | ClinicalTrials.gov |
| Conditions | Preterm Birth, Periodontal Disease, Caries, Dental | ClinicalTrials.gov |
| Interventions | Xylitol gum | ClinicalTrials.gov |
| Lead sponsor | Baylor College of Medicine | ClinicalTrials.gov |
| Results first posted | 2024-01-08 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT02333227?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.