Comparison · NCT02391337-deaths
Beta-blocker vs Digoxin: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Beta-blocker vs Digoxin: deaths from any cause. Trial comparisons, record NCT02391337-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02391337-deaths
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0875 | 0.043 | 0.17 | wilson | |
| Risk in group 2 | 0.0494 | 0.0194 | 0.12 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0381 | -0.0455 | 0.126 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.77 | 0.54 | 5.82 | log | |
| Odds ratio, group 1 over group 2 | 1.85 | 0.519 | 6.57 | log | |
| Number needed to harm, for one more death from any cause on Beta-blocker than on Digoxin | 26.2 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Beta-blocker | In Group B, oral bisoprolol will be commenced at either 1.25mg, 2.5mg or 5mg according to the treatment schedule and uptitrated, as required, to 15mg daily. Recommended additional therapy in this arm includes diltiazem. Use of digoxin is explicitly discouraged but will not terminate participation in the study. If intolerance to bisoprolol occurs, investigators will be advised to try an alternate beta-blocker of their choosing (typically carvedilol, nebivolol, or metoprolol) at equivalent dosage.~Bisoprolol: Drug intervention | 7 | 80 | EG000 |
| Group 2 | Digoxin | In Group A, the maintenance dose of oral digoxin will be either 62.5mcg or 125mcg according to the pre-defined treatment schedule and uptitrated, as required, to 250mcg daily. A single loading dose of four tablets (250 or 500mcg according to target maintenance dose) will be prescribed in digoxin-naïve participants, where necessary. Recommended additional therapy in this arm includes the calcium-channel blocker diltiazem. Use of beta-blockers is explicitly discouraged but will not terminate participation in the study.~Digoxin: Drug intervention | 4 | 81 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- During the 12 month follow-up period.
Source ClinicalTrials.gov
Trial
- Title
- Rate Control Therapy Evaluation in Permanent Atrial Fibrillation (RATE-AF)
- NCT number
- NCT02391337
- Phases
- PHASE4
- Conditions
- Permanent Atrial Fibrillation
- Interventions
- Bisoprolol, Digoxin
- Lead sponsor
- University of Birmingham
- Results first posted
- 2021-06-16
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02391337?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT02391337-deaths