Comparison · NCT02394951-77c02a6c
Pregabalin vs Placebo: Number of Patients With Significant Pain Reduction
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Pregabalin vs Placebo: Number of Patients With Significant Pain Reduction. Trial comparisons, record NCT02394951-77c02a6c. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02394951-77c02a6c
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.208 | 0.0924 | 0.405 | wilson | |
| Risk in group 2 | 0.125 | 0.0434 | 0.31 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0833 | -0.135 | 0.296 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.67 | 0.448 | 6.21 | log | |
| Odds ratio, group 1 over group 2 | 1.84 | 0.387 | 8.77 | log | |
| Number needed to treat, for one more participant with the outcome on Pregabalin than on Placebo | 12 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Pregabalin | Pregabalin administered for 4 weeks, titrated to highest tolerated dose up to 600 mg/day.~Pregabalin: Anticonvulsant~Placebo: Identical, matching inactive substance | 5 | 24 | OG000 |
| Group 2 | Placebo | Identical, matching inactive substance administered for 4 weeks following the same dosing regimen.~Pregabalin: Anticonvulsant~Placebo: Identical, matching inactive substance | 3 | 24 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Patients With Significant Pain Reduction
- Description
- Number of patients who experienced 50% or more reduction in average daily pain (on 0-10 NRS, Numerical Rating Scale, where 0=least pain, 10=worst pain)
- Time frame
- Baseline to week 4
- Population
Source ClinicalTrials.gov
Trial
- Title
- Pregabalin in CIPN
- NCT number
- NCT02394951
- Phases
- NA
- Conditions
- Neuropathy, Pain
- Interventions
- Pregabalin, Placebo
- Lead sponsor
- Washington University School of Medicine
- Results first posted
- 2019-05-14
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02394951?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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