Comparison · NCT02429427-d2e50ba9
Celecoxib vs Placebo: Cardiovascular Mortality
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Celecoxib vs Placebo: Cardiovascular Mortality. Trial comparisons, record NCT02429427-d2e50ba9. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02429427-d2e50ba9
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.00342 | 0.00157 | 0.00744 | wilson | |
| Risk in group 2 | 0.00576 | 0.00246 | 0.0134 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00234 | -0.0102 | 0.00286 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.594 | 0.182 | 1.94 | log | |
| Odds ratio, group 1 over group 2 | 0.592 | 0.18 | 1.95 | log | |
| Number needed to treat, for one fewer participant with the outcome on Celecoxib than on Placebo | 427 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Celecoxib | Patients in this arm will receive 400mg of celecoxib once daily. In addition, Hormone Receptor (+) patients will receive endocrine treatment according to local practice.~Celecoxib: Patients will receive 400mg of Celecoxib once daily for two years or until disease progression (if before the two years limit) or until development of unacceptable toxicities. In addition ER(+) patients will receive endocrine treatment according to local practice. | 6 | 1,755 | OG000 |
| Group 2 | Placebo | Patients in this arm will receive 2 tablets once daily. In addition Hormone Receptor (+) patients will receive endocrine treatment according to local practice.~Placebo: Two capsules once daily with food | 5 | 868 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Cardiovascular Mortality
- Description
- Number of deaths recorded as having cardiovascular involvement are reported by treatment group.
- Time frame
- Patients are followed up to 10 years, any deaths within this timeframe with cardiovascular involvement reported are included in the analysis.
- Population
- Safety population: This population includes all patients who start treatment, patients will be analysed by the treatment they received regardless of the group they were allocated to.
Source ClinicalTrials.gov
Trial
- Title
- European Celecoxib Trial in Primary Breast Cancer
- NCT number
- NCT02429427
- Phases
- PHASE3
- Conditions
- Breast Cancer
- Interventions
- Celecoxib, Placebo
- Lead sponsor
- Imperial College London
- Results first posted
- 2020-06-23
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02429427?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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