Comparison · NCT02434328-deaths
Brolucizumab 6mg vs Aflibercept 2mg: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Brolucizumab 6mg vs Aflibercept 2mg: deaths from any cause. Trial comparisons, record NCT02434328-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02434328-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0108 | 0.00421 | 0.0275 | wilson | |
| Risk in group 2 | 0.019 | 0.00922 | 0.0386 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00816 | -0.0289 | 0.0111 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.57 | 0.168 | 1.93 | log | |
| Odds ratio, group 1 over group 2 | 0.565 | 0.164 | 1.95 | log | |
| Number needed to treat, for one fewer death from any cause on Brolucizumab 6mg than on Aflibercept 2mg | 123 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Brolucizumab 6mg | All subjects exposed to brolucizumab ophthalmic solution administered as a 6 mg/50 microliter (μL) dose | 4 | 370 | EG000 |
| Group 2 | Aflibercept 2mg | All subjects exposed to aflibercept ophthalmic solution administered as a 2 mg/50 μL dose | 7 | 369 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- First treatment through study completion, an average of 96 weeks.
Source ClinicalTrials.gov
Trial
- Title
- Efficacy and Safety of RTH258 Versus Aflibercept - Study 2
- NCT number
- NCT02434328
- Phases
- PHASE3
- Conditions
- Neovascular Age-Related Macular Degeneration, Choroidal Neovascularization
- Interventions
- Brolucizumab ophthalmic solution, Aflibercept ophthalmic solution
- Lead sponsor
- Alcon Research
- Results first posted
- 2019-10-31
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02434328?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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GET https://conductscience.org/api/comparisons/v1/NCT02434328-deaths