Comparison · NCT02467621-b5357079
Proton Pump Inhibitor (PPI) vs Normal Saline: Number of Serious Adverse Reactions
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Proton Pump Inhibitor (PPI) vs Normal Saline: Number of Serious Adverse Reactions. Trial comparisons, record NCT02467621-b5357079. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02467621-b5357079
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0 | 0 | 0.00233 | wilson | |
| Risk in group 2 | 0 | 0 | 0.00233 | wilson | |
| Risk difference, group 1 minus group 2 | 0 | -0.00233 | 0.00233 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat | from the risk difference interval | the two groups' risks are equal |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Proton Pump Inhibitor (PPI) | Pantoprazole 40 mg~Pantoprazole: 40 mg x 1 daily intravenously from ICU admission to ICU discharge | 0 | 1,644 | OG000 |
| Group 2 | Normal Saline | Saline (0.9%)~Saline (0.9%): 10 ml of isotonic saline x 1 daily intravenously from ICU admission to ICU discharge | 0 | 1,647 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Serious Adverse Reactions
- Description
Serious adverse reactions are: anaphylactic reactions, agranulocytosis, pancytopenia, acute hepatic failure, Steven Johnsons Syndrome and toxic epidermal necrolysis, interstitial nephritis and angioedema.
- Time frame
- Until ICU discharge, maximum 90 days
- Population
Source ClinicalTrials.gov
Trial
- Title
- Stress Ulcer Prophylaxis in the Intensive Care Unit
- NCT number
- NCT02467621
- Phases
- PHASE4
- Conditions
- Gastrointestinal Bleeding, Stress Ulcers
- Interventions
- Pantoprazole, Saline (0.9%)
- Lead sponsor
- Dr. Morten Hylander Møller
- Results first posted
- 2019-06-07
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02467621?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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