Comparison · NCT02484859-8790b4e7
Remifentanil vs Tramadol + Metoprolol: Number of Participants With Postoperative Nausea and Vomiting
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Remifentanil vs Tramadol + Metoprolol: Number of Participants With Postoperative Nausea and Vomiting. Trial comparisons, record NCT02484859-8790b4e7. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02484859-8790b4e7
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.318 | 0.2 | 0.466 | wilson | |
| Risk in group 2 | 0.227 | 0.128 | 0.37 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0909 | -0.0943 | 0.268 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.4 | 0.698 | 2.81 | log | |
| Odds ratio, group 1 over group 2 | 1.59 | 0.615 | 4.1 | log | |
| Number needed to treat, for one more participant with the outcome on Remifentanil than on Tramadol + Metoprolol | 11 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Remifentanil | Following an intravenous bolus dose of 0.5 µg/kg remifentanil administered just before the induction of anaesthesia, patients will receive an intravenous infusion of remifentanil at a dose of 0.25-0.5 µg/kg/min throughout the surgery. The rate of infusion will be adjusted to maintain a mean blood pressure within %70-80 of the baseline value. At the end of the surgery, the rate of infusion will be decreased to 0.05 µg/kg/min, and continued until the patient is extubated. | 14 | 44 | OG000 |
| Group 2 | Tramadol + Metoprolol | Just before the induction of anaesthesia, an intravenous infusion of 1 mg/kg of tramadol in 100 ml isotonic fluid will be started. The infusion will be completed in 30 minutes using a perfusor. Additionally, following the administration of the neuromuscular blocking agent, 0.1 mg/kg of intravenous metoprolol will be administered within 5 minutes. | 10 | 44 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Postoperative Nausea and Vomiting
- Description
Postoperative nausea, retching, and vomiting on the day of surgery will be evaluated with a four-point ordinal scale (0-none, 1-nausea, 2-retching, 3-vomiting) at the post anaesthetic care unit, and the surgical ward. The evaluation will begin after the patient arrives at the post anaesthetic care unit, and will continue for 24 hours.
- Time frame
- following extubation, up to 24 hours
- Population
Source ClinicalTrials.gov
Trial
- Title
- Comparison of Metoprolol and Tramadol With Remifentanil in Endoscopic Sinus Surgery
- NCT number
- NCT02484859
- Phases
- PHASE4
- Conditions
- Nasal Polyps
- Interventions
- Remifentanil, Tramadol, Metoprolol
- Lead sponsor
- Recep Tayyip Erdogan University
- Results first posted
- 2019-09-10
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02484859?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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