Comparison · NCT02509078-sae
Early Neuromuscular Blockade (NMB) vs Control: No Routine Early NMB: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Early Neuromuscular Blockade (NMB) vs Control: No Routine Early NMB: serious adverse events. Trial comparisons, record NCT02509078-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02509078-sae
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0559 | 0.0389 | 0.0796 | wilson | |
| Risk in group 2 | 0.0416 | 0.0274 | 0.0627 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0143 | -0.0128 | 0.0419 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.34 | 0.774 | 2.33 | log | |
| Odds ratio, group 1 over group 2 | 1.36 | 0.764 | 2.44 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Early Neuromuscular Blockade (NMB) than on Control: No Routine Early NMB | 69.9 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Early Neuromuscular Blockade (NMB) | Patients will receive cisastracurium besylate for the first 48 hours of the trial.~cisastracurium besylate: Patients randomized to the early neuromuscular blockade arm will receive a cisastracurium besylate bolus of 15 mg, followed by a continuous infusion of 37.5 mg/hour for 48 hours. Patients randomized to the control arm will receive no protocol specified neuromuscular blockade. | 28 | 501 | EG000 |
| Group 2 | Control: No Routine Early NMB | Use of non-study NMB will be discouraged. Patients randomized to the control arm will receive no protocol specified neuromuscular blockade. | 21 | 505 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Subjects were assessed for occurrence of adverse events from time of randomization through study day 7 (five days after infusion of study drug) or ICU discharge, whichever occurred first.
Source ClinicalTrials.gov
Trial
- Title
- Reevaluation Of Systemic Early Neuromuscular Blockade
- NCT number
- NCT02509078
- Phases
- PHASE3
- Conditions
- Acute Respiratory Distress Syndrome
- Interventions
- Cisatracurium Besylate
- Lead sponsor
- Massachusetts General Hospital
- Results first posted
- 2019-08-13
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02509078?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT02509078-sae