Comparison · NCT02556710-sae
4 mL AMPION™ vs 4 mL Saline Placebo: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. 4 mL AMPION™ vs 4 mL Saline Placebo: serious adverse events. Trial comparisons, record NCT02556710-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02556710-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.00847 | 0.00233 | 0.0304 | wilson | |
| Risk in group 2 | 0.0165 | 0.00642 | 0.0416 | wilson | |
| Risk difference, group 1 minus group 2 | -0.00799 | -0.0338 | 0.0161 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.515 | 0.0952 | 2.78 | log | |
| Odds ratio, group 1 over group 2 | 0.511 | 0.0926 | 2.81 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on 4 mL AMPION™ than on 4 mL Saline Placebo | 125 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | 4 mL AMPION™ | AMPION™: 4 mL Ampion Injection | 2 | 236 | EG000 |
| Group 2 | 4 mL Saline Placebo | Saline: 4 mL Saline Injection | 4 | 243 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- 12 Weeks
Source ClinicalTrials.gov
Trial
- Title
- A Study to Evaluate the Efficacy & Safety of an Intra-Articular Ampion Injection for Pain of Osteoarthritis of the Knee
- NCT number
- NCT02556710
- Phases
- PHASE3
- Conditions
- Osteoarthritis of the Knee
- Interventions
- 4 mL injection of AMPION™, 4 mL injection of Placebo
- Lead sponsor
- Ampio Pharmaceuticals. Inc.
- Results first posted
- 2022-08-08
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02556710?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
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GET https://conductscience.org/api/comparisons/v1/NCT02556710-sae