Comparison · NCT02561702-aeea925d
Mexiletine vs Placebo: Number of Participants With a Decrease in Cramp Intensity
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Mexiletine vs Placebo: Number of Participants With a Decrease in Cramp Intensity. Trial comparisons, record NCT02561702-aeea925d. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02561702-aeea925d
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.25 | 0.0456 | 0.699 | wilson | |
| Risk in group 2 | 0.5 | 0.15 | 0.85 | wilson | |
| Risk difference, group 1 minus group 2 | -0.25 | -0.655 | 0.32 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.5 | 0.0704 | 3.55 | log | |
| Odds ratio, group 1 over group 2 | 0.333 | 0.0167 | 6.65 | log | |
| Number needed to treat, for one fewer participant with the outcome on Mexiletine than on Placebo | 4 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Mexiletine | Participants will receive 150 mg of mexiletine by mouth 3 times daily for 5-7 days followed by 7 day washout period and 5-7 days of placebo (240 mg of lactose powder) taken by mouth 3 times daily~Placebo: 240 mg lactose powder in a size 3 capsule taken by mouth 3 times daily for 5-7 days~Mexiletine: 150 mg Mexiletine taken by mouth in capsule form 3 times daily for 5-7 days | 1 | 4 | OG000 |
| Group 2 | Placebo | Participants will receive placebo (240 mg of lactose powder) taken by mouth 3 times daily for 5-7 days followed by 7 day washout period and 5-7 days of 150 mg of mexiletine by mouth 3 times daily~Placebo: 240 mg lactose powder in a size 3 capsule taken by mouth 3 times daily for 5-7 days~Mexiletine: 150 mg Mexiletine taken by mouth in capsule form 3 times daily for 5-7 days | 2 | 4 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Participants With a Decrease in Cramp Intensity
- Description
Participant will be evaluated for muscle cramps 120 minutes following a single dose of oral mexiletine. The Clinical Evaluator applied pressure to provoke hamstring cramps bilaterally, one at a time 2 hours after dose. The cramp intensity of the right hamstring was reported by the subject on a scale of 1-10 with 1 being weak and 10 being severe.
- Time frame
- 120 minutes
- Population
Source ClinicalTrials.gov
Trial
- Title
- Mexiletine for Muscle Cramps in Charcot Marie Tooth Disease
- NCT number
- NCT02561702
- Phases
- PHASE2
- Conditions
- Charcot Marie Tooth Disease
- Interventions
- Placebo, Mexiletine
- Lead sponsor
- University of Rochester
- Results first posted
- 2018-03-26
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02561702?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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