Comparison · NCT02608489-0ef04c59
Diqufosol vs Hyaluronate: Number of Participants Who Stop Using the Eye Drops Due to Drug-related Discomfort
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Diqufosol vs Hyaluronate: Number of Participants Who Stop Using the Eye Drops Due to Drug-related Discomfort. Trial comparisons, record NCT02608489-0ef04c59. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02608489-0ef04c59
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0323 | 0.00572 | 0.162 | wilson | |
| Risk in group 2 | 0 | 0 | 0.104 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0323 | -0.0753 | 0.162 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat, for one more participant with the outcome on Diqufosol than on Hyaluronate | 31 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Diqufosol | 3% Diquafosol Tetrasodium Ophthalmic Solution~Diquafosol (Diquas): Diquafosol group used diquafosol 6 times a day during study period. | 1 | 31 | OG000 |
| Group 2 | Hyaluronate | 0.1% Sodium Hyaluronate Ophthalmic Solution~Sodium Hyaluronate (Hyalein): Hyaluronate group used sodium hyaluronate 6 times a day during study period. | 0 | 33 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants Who Stop Using the Eye Drops Due to Drug-related Discomfort
- Description
Drug-related discomfort is defined as having started after eye drop instillation and lasting several minutes, occurring every time during instillation at any time up to 12 weeks into the follow-up period. Patients that had any adverse events or wanted to stop using the eye drops were excluded from the study, but these patients were included in the safety evaluation.
- Time frame
- 12 weeks
- Population
- Overall, 1 of 31 patients (3.22%), a 64-year-old man who underwent bilateral sequential same-day cataract surgery, stopped using the study eye drops owing to severe irritation in the D group.
Source ClinicalTrials.gov
Trial
- Title
- Clinical Effects and Safety of 3% Diquafosol After Cataract Surgery
- NCT number
- NCT02608489
- Phases
- NA
- Conditions
- Dry Eye Syndromes
- Interventions
- Diquafosol (Diquas), Sodium Hyaluronate (Hyalein)
- Lead sponsor
- Soonchunhyang University Hospital
- Results first posted
- 2016-10-17
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02608489?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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