Comparison · NCT02625974-2bb15768
Nifurtimox 60 Days / Arm 1 vs Nifurtimox 30 Days, Then Placebo 30 Days / Arm 2: Part 1 - Number of Subjects With Abnormal ECG Findings Considered as Clinically Significant by Investigators
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Nifurtimox 60 Days / Arm 1 vs Nifurtimox 30 Days, Then Placebo 30 Days / Arm 2: Part 1 - Number of Subjects With Abnormal ECG Findings Considered as Clinically Significant by Investigators. Trial comparisons, record NCT02625974-2bb15768. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02625974-2bb15768
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0 | 0 | 0.0172 | wilson | |
| Risk in group 2 | 0 | 0.00000000000000000347 | 0.0335 | wilson | |
| Risk difference, group 1 minus group 2 | 0 | -0.0335 | 0.0172 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | log | a group has no participants with the outcome | |||
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat | from the risk difference interval | the two groups' risks are equal |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Nifurtimox 60 Days / Arm 1 | Nifurtimox tablets administered three times daily for 60 days (Days 1 - 60, active nifurtimox treatment) | 0 | 219 | OG000 |
| Group 2 | Nifurtimox 30 Days, Then Placebo 30 Days / Arm 2 | Nifurtimox tablets administered three times daily for 30 days, followed by placebo administered three times daily for 30 days (Days 1 - 30, active nifurtimox treatment; Days 31 - 60, placebo) | 0 | 111 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Part 1 - Number of Subjects With Abnormal ECG Findings Considered as Clinically Significant by Investigators
- Description
- Clinical significance of abnormal ECG was based on the judgement of the investigator
- Time frame
- Up to 420 days (Visit 11 post-treatment)
- Population
Source ClinicalTrials.gov
Trial
- Title
- A Study to Learn How Well Nifurtimox Works and How Safe it is in Children Aged 0 to 17 Years With Chagas' Disease, an Inflammatory, Infectious Disease Caused by the Parasite Trypanosoma Cruzi
- NCT number
- NCT02625974
- Phases
- PHASE3
- Conditions
- Chagas Disease
- Interventions
- Nifurtimox (Lampit, BAYA2502), Placebo
- Lead sponsor
- Bayer
- Results first posted
- 2019-10-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02625974?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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