Comparison · NCT02643381-sae
Etomidate vs Ketamine: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Etomidate vs Ketamine: serious adverse events. Trial comparisons, record NCT02643381-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02643381-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0253 | 0.0138 | 0.0459 | wilson | |
| Risk in group 2 | 0.0228 | 0.012 | 0.0427 | wilson | |
| Risk difference, group 1 minus group 2 | 0.00247 | -0.0205 | 0.0257 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.11 | 0.455 | 2.7 | log | |
| Odds ratio, group 1 over group 2 | 1.11 | 0.447 | 2.76 | log | |
| Number needed to harm, for one more participant with a serious adverse event on Etomidate than on Ketamine | 405 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Etomidate | Patients randomized to this group will receive etomidate immediately prior to emergency endotracheal intubation.~Etomidate: Patients randomized to this group will receive etomidate immediately prior to emergency endotracheal intubation.~Emergency Endotracheal Intubation: Patients enrolled in the study will be endotracheally intubated. (A breathing tube will be placed into the patient's mouth and trachea). This procedure is being done as part of standard emergency care. Standard endotracheal tubes will be used. Our hospital uses primarily Mallinckrodt (TM) brand endotracheal tubes.~Mechanical Ventilation: Patients enrolled in the study will be mechanically ventilated, using a standard ventilator used in our hospital. The mechanical ventilator is attached to the patient's endotracheal tube and helps sustain the patient's life. Our hospital uses several brands of mechanical ventilators. | 10 | 396 | EG000 |
| Group 2 | Ketamine | Patients randomized to this group will receive ketamine immediately prior to emergency endotracheal intubation.~Ketamine: Patients randomized to this group will receive ketamine immediately prior to emergency endotracheal intubation.~Emergency Endotracheal Intubation: Patients enrolled in the study will be endotracheally intubated. (A breathing tube will be placed into the patient's mouth and trachea). This procedure is being done as part of standard emergency care. Standard endotracheal tubes will be used. Our hospital uses primarily Mallinckrodt (TM) brand endotracheal tubes.~Mechanical Ventilation: Patients enrolled in the study will be mechanically ventilated, using a standard ventilator used in our hospital. The mechanical ventilator is attached to the patient's endotracheal tube and helps sustain the patient's life. Our hospital uses several brands of mechanical ventilators. | 9 | 395 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Day 1-28
Source ClinicalTrials.gov
Trial
- Title
- Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial
- NCT number
- NCT02643381
- Phases
- PHASE4
- Conditions
- Cardiopulmonary Arrest, Respiratory Arrest
- Interventions
- Etomidate, Ketamine, Emergency Endotracheal Intubation, Mechanical Ventilation
- Lead sponsor
- University of Texas Southwestern Medical Center
- Results first posted
- 2021-12-15
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02643381?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
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