Comparison · NCT02646982-16df4e7a
Candesartan vs Placebo: Number of Participants With Hypotensive Episodes and Symptoms
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Candesartan vs Placebo: Number of Participants With Hypotensive Episodes and Symptoms. Trial comparisons, record NCT02646982-16df4e7a. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02646982-16df4e7a
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.105 | 0.0417 | 0.241 | wilson | |
| Risk in group 2 | 0.0256 | 0.00454 | 0.132 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0796 | -0.0441 | 0.217 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 4.11 | 0.48 | 35.1 | log | |
| Odds ratio, group 1 over group 2 | 4.47 | 0.476 | 42 | log | |
| Number needed to treat, for one more participant with the outcome on Candesartan than on Placebo | 12.6 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Candesartan | Participants receiving candesartan given orally once a day in a stepwise manner. Participants were initiated on 8 mg candesartan. The dose was increased in 2 week increments to 16 mg and 32 mg, as tolerated. The highest achievable dose was the Maximal Tolerated Dose (MTD) and the participant received this dose for the remaining duration of the study (12 months total). | 4 | 38 | OG000 |
| Group 2 | Placebo | Participants receiving a placebo to match candesartan once a day orally for 12 months. | 1 | 39 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Participants With Hypotensive Episodes and Symptoms
- Description
- The number of participants with reported episodes hypotension as well as symptoms of hypotension.
- Time frame
- Up to Month 12
- Population
Source ClinicalTrials.gov
Trial
- Title
- Candesartan's Effects on Alzheimer's Disease And Related Biomarkers
- NCT number
- NCT02646982
- Phases
- PHASE2
- Conditions
- Mild Cognitive Impairment
- Interventions
- Placebo, Candesartan
- Lead sponsor
- Emory University
- Results first posted
- 2022-09-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02646982?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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