Comparison · NCT02684006-a0948b30
Avelumab + Axitinib vs Sunitinib: Number of Participants Who Discontinued Treatment Due to Toxicity
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Avelumab + Axitinib vs Sunitinib: Number of Participants Who Discontinued Treatment Due to Toxicity. Trial comparisons, record NCT02684006-a0948b30. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02684006-a0948b30
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.313 | 0.272 | 0.358 | wilson | |
| Risk in group 2 | 0.148 | 0.118 | 0.184 | wilson | |
| Risk difference, group 1 minus group 2 | 0.165 | 0.11 | 0.22 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 2.12 | 1.63 | 2.76 | log | |
| Odds ratio, group 1 over group 2 | 2.63 | 1.88 | 3.66 | log | |
| Number needed to treat, for one more participant with the outcome on Avelumab + Axitinib than on Sunitinib | 6.05 | 4.55 | 9.1 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Avelumab + Axitinib | Participants with aRCC received avelumab 10 mg/kg, IV at Q2W in a 6-week cycle plus axitinib 5 mg, orally BID. Each treatment cycle was 42 days. | 136 | 434 | OG000 |
| Group 2 | Sunitinib | Participants with aRCC received sunitinib 50 mg orally, QD on a schedule of 4 weeks on treatment followed by 2 weeks off treatment (schedule 4/2 in 6-week cycles). Each treatment cycle was of 42 days. | 65 | 439 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants Who Discontinued Treatment Due to Toxicity
- Description
- Number of participants who discontinued treatment due to toxicity are reported in this outcome measure.
- Time frame
- From first dose of study treatment until discontinuation of study treatment (maximum up to approximately 89 months)
- Population
- Safety analysis set included all participants who received at least one dose of study drug.
Source ClinicalTrials.gov
Trial
- Title
- A Study of Avelumab With Axitinib Versus Sunitinib In Advanced Renal Cell Cancer (JAVELIN Renal 101)
- NCT number
- NCT02684006
- Phases
- PHASE3
- Conditions
- Renal Cell Cancer
- Interventions
- Avelumab (MSB0010718C), Axitinib (AG-013736), Sunitinib
- Lead sponsor
- Pfizer
- Results first posted
- 2024-10-29
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02684006?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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