Comparison · NCT02685709-89992bce
RCT Phase - Oral vs RCT Phase - Injectables: Proportion of Patients Who Maintain or Improve Their Overall Acromegaly Index of Severity (AIS) Score at the End of the RCT Phase
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. RCT Phase - Oral vs RCT Phase - Injectables: Proportion of Patients Who Maintain or Improve Their Overall Acromegaly Index of Severity (AIS) Score at the End of the RCT Phase. Trial comparisons, record NCT02685709-89992bce. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02685709-89992bce
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.727 | 0.598 | 0.827 | wilson | |
| Risk in group 2 | 0.676 | 0.515 | 0.804 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0516 | -0.131 | 0.241 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.08 | 0.817 | 1.42 | log | |
| Odds ratio, group 1 over group 2 | 1.28 | 0.516 | 3.18 | log | |
| Number needed to treat, for one more participant with the outcome on RCT Phase - Oral than on RCT Phase - Injectables | 19.4 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | RCT Phase - Oral | Oral octreotide capsules~Octreotide capsules: Octreotide capsules 40mg/day, 60mg/day, 80mg/day | 40 | 55 | OG000 |
| Group 2 | RCT Phase - Injectables | Injectable somatostatin analogs (octreotide or lanreotide)~Injectable Somatostatin Analogs (octreotide or lanreotide): Octreotide - 10, 20, 30mg. Lanreotide 60,90, 120mg. | 25 | 37 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Proportion of Patients Who Maintain or Improve Their Overall Acromegaly Index of Severity (AIS) Score at the End of the RCT Phase
- Description
Proportion of patients who maintain or improve their overall Acromegaly index of severity (AIS) score at the end of the RCT phase (improvement defined as a reduction of at least one point in the AIS score), compared to week 26 (start of the RCT phase)
- Time frame
- 62 weeks
- Population
Source ClinicalTrials.gov
Trial
- Title
- Comparison of Oral Octreotide Capsules to Injectable Somatostatin Analogs in Acromegaly
- NCT number
- NCT02685709
- Phases
- PHASE3
- Conditions
- Acromegaly
- Interventions
- Octreotide capsules
- Lead sponsor
- Chiasma, Inc.
- Results first posted
- 2022-04-22
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02685709?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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