Comparison · NCT02688400-503c62ef
Diacerein vs Celecoxib: OARSI Responders
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Diacerein vs Celecoxib: OARSI Responders. Trial comparisons, record NCT02688400-503c62ef. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02688400-503c62ef
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.541 | 0.469 | 0.612 | wilson | |
| Risk in group 2 | 0.519 | 0.447 | 0.589 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0223 | -0.0787 | 0.123 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.04 | 0.861 | 1.26 | log | |
| Odds ratio, group 1 over group 2 | 1.09 | 0.727 | 1.65 | log | |
| Number needed to treat, for one more participant with the outcome on Diacerein than on Celecoxib | 44.9 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Diacerein | One placebo capsule once daily in the morning (breakfast) and one diacerein 50 mg capsule once daily in the evening (dinner) for the first month, then diacerein capsules twice daily with meals in the morning (breakfast) and the evening (dinner).~Diacerein~Placebo | 99 | 183 | OG000 |
| Group 2 | Celecoxib | One celecoxib 200 mg capsule once daily in the morning (breakfast) and one placebo capsule once daily in the evening (dinner).~Celecoxib~Placebo | 97 | 187 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- OARSI Responders
- Description
- Osteoarthritis Research Society International (OARSI) Responders
- Time frame
- Day 182 or early termination
- Population
- Intentio-to-treat
Source ClinicalTrials.gov
Trial
- Title
- Effect of Diacerein vs Celecoxib on Symptoms and Structural Changes in Symptomatic Knee Osteoarthritis
- NCT number
- NCT02688400
- Phases
- PHASE3
- Conditions
- Osteoarthritis, Osteoarthritis, Knee
- Interventions
- Diacerein, Celecoxib, Placebo
- Lead sponsor
- TRB Chemedica International SA
- Results first posted
- 2023-12-01
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02688400?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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