Comparison · NCT02692716-2dfd9f93
Oral Semaglutide vs Placebo: Time From Randomisation to All-cause Death
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Oral Semaglutide vs Placebo: Time From Randomisation to All-cause Death. Trial comparisons, record NCT02692716-2dfd9f93. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02692716-2dfd9f93
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0145 | 0.00965 | 0.0216 | wilson | |
| Risk in group 2 | 0.0283 | 0.0212 | 0.0376 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0138 | -0.0243 | -0.00376 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.511 | 0.311 | 0.841 | log | |
| Odds ratio, group 1 over group 2 | 0.504 | 0.304 | 0.837 | log | |
| Number needed to treat, for one fewer participant with the outcome on Oral Semaglutide than on Placebo | 72.4 | 41.1 | 266 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Oral Semaglutide | Participants were to take once-daily semaglutide tablets in a dose escalation manner for upto 82 weeks: 3 mg from week 0 to week 4, 7 mg from week 4 to week 8 and 14 mg from week 9 to upto week 82. | 23 | 1,591 | OG000 |
| Group 2 | Placebo | Participants were to take oral semaglutide placebo tablets once-daily for a period of upto 82 weeks. | 45 | 1,592 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Time From Randomisation to All-cause Death
- Description
Number of all-cause deaths in the study are presented. Results are based on the in-trial observation period which started at the date of randomisation, included the period after permanent trial product discontinuation, if any and ended at the date of the follow-up visit regardless of adherence to treatment.
- Time frame
- Maximum treatment duration is dependent on event rates and is expected to be no longer than 19 months + 5 weeks of follow-up period.
- Population
- Overall number of participants analyzed = FAS which comprised all randomised participants.
Source ClinicalTrials.gov
Trial
- Title
- A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes
- NCT number
- NCT02692716
- Phases
- PHASE3
- Conditions
- Diabetes, Diabetes Mellitus, Type 2
- Interventions
- semaglutide, placebo
- Lead sponsor
- Novo Nordisk A/S
- Results first posted
- 2020-02-27
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02692716?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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