Comparison · NCT02715726-deaths
Ezetimibe 10 mg vs Alirocumab 75 mg Q2W/up150 mg Q2W: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Ezetimibe 10 mg vs Alirocumab 75 mg Q2W/up150 mg Q2W: deaths from any cause. Trial comparisons, record NCT02715726-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02715726-deaths
On this page
Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0146 | 0.00496 | 0.0419 | wilson | |
| Risk in group 2 | 0.00493 | 0.00135 | 0.0178 | wilson | |
| Risk difference, group 1 minus group 2 | 0.00964 | -0.00641 | 0.0372 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 2.96 | 0.498 | 17.6 | log | |
| Odds ratio, group 1 over group 2 | 2.99 | 0.495 | 18 | log | |
| Number needed to harm, for one more death from any cause on Ezetimibe 10 mg than on Alirocumab 75 mg Q2W/up150 mg Q2W | 104 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Ezetimibe 10 mg | Oral ezetimibe 10 mg capsule once daily with or without food for 24 weeks and subcutaneous placebo injection for alirocumab Q2W for 22 weeks added to LMT. | 3 | 206 | EG000 |
| Group 2 | Alirocumab 75 mg Q2W/up150 mg Q2W | Subcutaneous injection of alirocumab 75 mg Q2W and oral placebo capsule for ezetimibe once daily with or without food added to stable LMT for 24 weeks. Alirocumab dose up-titrated to 150 mg Q2W from Week 12 when LDL-C level was \>=70 mg/dL (1.81 mmol/L) at Week 8. | 2 | 406 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- All Adverse Events (AEs) were collected from signature of the informed consent form up to 32 weeks of the study regardless of seriousness or relationship to investigational product.
Source ClinicalTrials.gov
Trial
- Title
- Evaluation of Alirocumab Versus Ezetimibe on Top of Statin in Asia in High Cardiovascular Risk Patients With Hypercholesterolemia
- NCT number
- NCT02715726
- Phases
- PHASE3
- Conditions
- Hypercholesterolemia
- Interventions
- Alirocumab, Placebo for alirocumab, ezetimibe, placebo for ezetimibe, atorvastatin, rosuvastatin, simvastatin
- Lead sponsor
- Sanofi
- Results first posted
- 2019-09-30
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02715726?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
Read this comparison from software.
The record is JSON. No key.
GET https://conductscience.org/api/comparisons/v1/NCT02715726-deaths