Comparison · NCT02804750-eeae3e70
Group 1: Low-dose Group vs Group 2: High-dose Group: Percentage of Participants With One or More Severe (≥Grade 3) Adverse Events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Group 1: Low-dose Group vs Group 2: High-dose Group: Percentage of Participants With One or More Severe (≥Grade 3) Adverse Events. Trial comparisons, record NCT02804750-eeae3e70. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02804750-eeae3e70
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.176 | 0.0619 | 0.41 | wilson | |
| Risk in group 2 | 0.389 | 0.203 | 0.614 | wilson | |
| Risk difference, group 1 minus group 2 | -0.212 | -0.465 | 0.0863 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.454 | 0.14 | 1.48 | log | |
| Odds ratio, group 1 over group 2 | 0.337 | 0.0703 | 1.61 | log | |
| Number needed to treat, for one fewer participant with the outcome on Group 1: Low-dose Group than on Group 2: High-dose Group | 4.71 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Group 1: Low-dose Group | 100 mg/day for 4 weeks in Period 1, then 150 mg/day for 4 weeks in Period 2, then 200 mg/day for 4 weeks in Period 3. Period 3 was followed by a 4-week follow-up period. | 3 | 17 | OG000 |
| Group 2 | Group 2: High-dose Group | 250 mg/day for 4 weeks in Period 1, then 300 mg/day for 4 weeks in Period 2, then 350 mg/day for 4 weeks in Period 3, then 400 mg/day for 4 weeks in Period 4. Period 4 was followed by a 4-week follow-up period. | 7 | 18 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Percentage of Participants With One or More Severe (≥Grade 3) Adverse Events
- Description
- All treatment-emergent adverse events with Common Terminology Criteria for Adverse Events (CTCAE) ≥Grade 3 (severe) were recorded and summarized.
- Time frame
- Group 1: up to Week 16; Group 2: up to Week 20
- Population
- All enrolled participants who received at least 1 dose of study drug
Source ClinicalTrials.gov
Trial
- Title
- Study to Evaluate CORT125134 in Participants With Cushing's Syndrome
- NCT number
- NCT02804750
- Phases
- PHASE2
- Conditions
- Cushing's Syndrome
- Interventions
- CORT125134
- Lead sponsor
- Corcept Therapeutics
- Results first posted
- 2019-09-25
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02804750?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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