Comparison · NCT02808507-925fb897
Contact Tracing Household-based Sub-arm vs Contact Tracing Incentive-based Sub-arm: Comparative Treatment Initiation Ratio in the Incentive-based Versus Household-based Contact Investigation Arms
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Contact Tracing Household-based Sub-arm vs Contact Tracing Incentive-based Sub-arm: Comparative Treatment Initiation Ratio in the Incentive-based Versus Household-based Contact Investigation Arms. Trial comparisons, record NCT02808507-925fb897. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02808507-925fb897
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 1 | 0.997 | 1 | wilson | |
| Risk in group 2 | 1 | 0.997 | 1 | wilson | |
| Risk difference, group 1 minus group 2 | 0 | -0.00271 | 0.00254 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1 | 1 | 1 | log | |
| Odds ratio, group 1 over group 2 | log | a cell of the two-by-two table is zero | |||
| Number needed to treat | from the risk difference interval | the two groups' risks are equal |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Contact Tracing Household-based Sub-arm | This strategy will be implemented for 18 months at half of the clinics within the contact tracing arm (n=14) and, after a six-month washout period, for 18 months in the other half of the clinics in that arm (n = 14). All adults (and guardians for children) with newly diagnosed pulmonary TB will be approached for enrolment as described above. Consenting patients (estimated as 1,575 subjects) will be asked for a home address (with landmarks), mobile phone number, and convenient time for a household visit. A mobile field team consisting of a nurse and lay health worker (both research staff) will circulate between the 14 primary care clinics, with notifications of all new TB cases made from the clinic to the team by mobile phone. The field team will visit the household of each consenting index case within two weeks of notification; each visit will consist of a household census (including demographic data), consent of all eligible household members for questioning and TB screening, administration of a brief questionnaire (including symptomatology, self-reported HIV and TB history, care-seeking behavior, and acceptability of the intervention), and sputum collection for testing with Xpert MTB/RIF. Each participant will also be offered voluntary HIV counselling and testing. The team will make up to three visits to each household as needed in order to approach all household contacts for study enrolment. | 1,413 | 1,413 | OG000 |
| Group 2 | Contact Tracing Incentive-based Sub-arm | This strategy will be implemented in the opposite half of the clinics randomized to contact investigation. All adults (and guardians of children) with newly diagnosed active TB will be identified and approached for enrolment as described above. However, rather than a household visit, each consenting individual will be provided with a set of 10 coupons to give to household members and close contacts whom the index case believes may be at greatest risk. These coupons will contain instructions on how to come to the clinic for free TB screening (e.g., when the study team will be at each clinic), and will have an expiration date of 2 months from the time of initial TB diagnosis. When a contact presents at the clinic with the coupon, the contact will receive a small amount of money and a transport allowance based on the distance travelled to the clinic. If the contact is diagnosed with active TB and starts treatment, the contact will receive an additional larger amount of money. Study staff will document which index case the contact is linked to, and whether the contact is diagnosed with active TB. At the end of the 2 month period in which the coupons are valid the index will receive a grocery voucher for the total incentive earned (e.g., total amount for contact(s) who presented for screening + total amount for contact(s) diagnosed with active TB and starting treatment). | 1,510 | 1,510 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Comparative Treatment Initiation Ratio in the Incentive-based Versus Household-based Contact Investigation Arms
- Description
The primary outcome of the study was the comparative number of people with incident TB diagnosed and started on treatment at study clinics in the two contact tracing arms, excluding the six-month washout period.
- Time frame
- 36 months
- Population
This analysis population includes all participants enrolled in the two contact tracing sub-arms during the total study period of 36 months. It excludes participants from the facility-based screening arm. A total of 2,923 patients were started on TB treatment during the study period: 1,413 in clinics allocated to household-based contact investigation and 1,510 in clinics allocated to incentive-based contact investigation.
Source ClinicalTrials.gov
Trial
- Title
- Comparative Effectiveness/Implementation of TB Case Finding in Rural South Africa
- NCT number
- NCT02808507
- Phases
- NA
- Conditions
- Tuberculosis
- Interventions
- Active TB case finding
- Lead sponsor
- Johns Hopkins Bloomberg School of Public Health
- Results first posted
- 2022-12-02
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02808507?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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