Comparison · NCT02838420-deaths
Alectinib vs Crizotinib: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Alectinib vs Crizotinib: deaths from any cause. Trial comparisons, record NCT02838420-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02838420-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.064 | 0.0328 | 0.121 | wilson | |
| Risk in group 2 | 0.21 | 0.127 | 0.326 | wilson | |
| Risk difference, group 1 minus group 2 | -0.146 | -0.266 | -0.045 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.305 | 0.134 | 0.697 | log | |
| Odds ratio, group 1 over group 2 | 0.258 | 0.1 | 0.661 | log | |
| Number needed to treat, for one fewer death from any cause on Alectinib than on Crizotinib | 6.86 | 3.75 | 22.2 | from the risk difference interval |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Alectinib | Participants received alectinib capsules orally at a dose of 600 mg twice a day (BID) with food until disease progression, unacceptable toxicity withdrawal of consent, or death. | 8 | 125 | EG000 |
| Group 2 | Crizotinib | Participants received crizotinib capsules orally at a dose of 250 mg BID with or without food until disease progression, unacceptable toxicity, withdrawal of consent, or death. | 13 | 62 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- Up to approximately 40 months
Source ClinicalTrials.gov
Trial
- Title
A Study to Evaluate and Compare the Efficacy and Safety of Alectinib Versus Crizotinib and to Evaluate the Pharmacokinetics of Alectinib in Asian Participants With Treatment-Naive Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small Cell Lung Cancer (NSCLC)
- NCT number
- NCT02838420
- Phases
- PHASE3
- Conditions
- Anaplastic Lymphoma Kinase-positive Non-small Cell Lung Cancer
- Interventions
- Alectinib, Crizotinib
- Lead sponsor
- Hoffmann-La Roche
- Results first posted
- 2019-07-11
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02838420?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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