5ARI Users vs Non 5ARI Users: Suicide (Based on Administrative Data Elements From Ontario Registrar General Death Database, National Ambulatory Care Reporting System, Hospital Discharge Abstracts, and Ontario Regional Mental Health Database)
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.000408 | 0.000297 | 0.00056 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.000386 | 0.000279 | 0.000535 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | 0.0000215 | -0.000164 | 0.000207 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 1.06 | 0.669 | 1.67 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 1.06 | 0.669 | 1.67 | log | ClinicalTrials.gov | |
| Number needed to treat, for one more participant with the outcome on 5ARI Users than on Non 5ARI Users | 46,600 | from the risk difference interval | the interval includes no difference | ClinicalTrials.gov |
Groups 2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | 5ARI Users | 5ARI: Exposure to finasteride/dutasteride | 38 | 93,197 | OG000 | ClinicalTrials.gov |
| Group 2 | Non 5ARI Users | 36 | 93,197 | OG001 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | PRIMARY | ClinicalTrials.gov |
| Title | Suicide (Based on Administrative Data Elements From Ontario Registrar General Death Database, National Ambulatory Care Reporting System, Hospital Discharge Abstracts, and Ontario Regional Mental Health Database) | ClinicalTrials.gov |
| Description | 1. Ontario Registrar General Death database. Use the COD\_primary variable (used from 2003 onwards) to define suicide, based on an ICD10 code of X60-X84.~2. NACRS: X60-84 (dx10code1-dx10code10) AND dead on arrival or death after arrival (visdisp2002 = 10 or 11). Consider admission date the date of the event.~3. OMHRS: Discharge reason (dischreason (X90) = 2). Died from suicide. Consider admission date the date of the event.~4. CIHI-DAD (Consider admission date the date of the event):~i. suicide=1, or ii. dx10code1-25= ICD10 X60-84 AND dischdisp=07. | ClinicalTrials.gov |
| Time frame | Through study completition, an average of 18 months. | ClinicalTrials.gov |
| Population | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | 5 Alpha Reductase Inhibitors And The Risk Of Suicide And Depression | ClinicalTrials.gov |
| NCT number | NCT02876757 | ClinicalTrials.gov |
| Phases | ClinicalTrials.gov | |
| Conditions | BPH, Depression, Suicide | ClinicalTrials.gov |
| Interventions | 5ARI | ClinicalTrials.gov |
| Lead sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | ClinicalTrials.gov |
| Results first posted | 2018-02-05 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT02876757?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.