5ARI Users vs Non 5ARI Users: Depression (Based on Administrative Data Elements From Hospital Discharge Abstract Database, and Ontario Regional Mental Health Database and Ontario Health Insurance Plan)
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
Measures 6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note | Source |
|---|---|---|---|---|---|---|
| Risk in group 1 | 0.0195 | 0.0186 | 0.0204 | wilson | ClinicalTrials.gov | |
| Risk in group 2 | 0.0137 | 0.013 | 0.0145 | wilson | ClinicalTrials.gov | |
| Risk difference, group 1 minus group 2 | 0.00578 | 0.0046 | 0.00696 | newcombe hybrid score | ClinicalTrials.gov | |
| Risk ratio, group 1 over group 2 | 1.42 | 1.32 | 1.53 | log | ClinicalTrials.gov | |
| Odds ratio, group 1 over group 2 | 1.43 | 1.33 | 1.54 | log | ClinicalTrials.gov | |
| Number needed to treat, for one more participant with the outcome on 5ARI Users than on Non 5ARI Users | 173 | 144 | 218 | from the risk difference interval | ClinicalTrials.gov |
Groups 2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code | Source |
|---|---|---|---|---|---|---|
| Group 1 | 5ARI Users | 5ARI: Exposure to finasteride/dutasteride | 1,750 | 89,844 | OG000 | ClinicalTrials.gov |
| Group 2 | Non 5ARI Users | 1,231 | 89,844 | OG001 | ClinicalTrials.gov |
Outcome 5
| Field | Value | Source |
|---|---|---|
| Type | SECONDARY | ClinicalTrials.gov |
| Title | Depression (Based on Administrative Data Elements From Hospital Discharge Abstract Database, and Ontario Regional Mental Health Database and Ontario Health Insurance Plan) | ClinicalTrials.gov |
| Description | 1. Any CIHI-DAD/SDS ICD 10 code, OR~2. Any OMRHS code Axis1\_dsm4code1-19 or Axis2\_dsm4code 1-7 OR~3. Look for any OHIP record billed by Mainspecialty = PSYCHIATRY with a diagnosis of depression OHIP dxcode 311, OR~4. ≥2 GP visits within 2 years AND both with OHIP dxcode 311~i. OHIP dxcode: 311 ii. ICD 10: F32.0, F32.1, F32.2, F32.3, F32.8, F32.9, F33.0, F33.1, F33.2, F33.3, F33.4, F33.8, F34.1 iii. Psychiatry visits defined as any of these OHIP fee codes: A195, A895, A190, A795, A695, A395, A196, A193, A194, A191, A192 iv. OMHRS: 29620-29626, 29630-29636, 31100 (major depressive disorder) | ClinicalTrials.gov |
| Time frame | Through study completition, an average of 18 months. | ClinicalTrials.gov |
| Population | This population is restricted to those who had no history of depression, thus it is a subgroup of the total study population. | ClinicalTrials.gov |
Trial 8
| Field | Value | Source |
|---|---|---|
| Title | 5 Alpha Reductase Inhibitors And The Risk Of Suicide And Depression | ClinicalTrials.gov |
| NCT number | NCT02876757 | ClinicalTrials.gov |
| Phases | ClinicalTrials.gov | |
| Conditions | BPH, Depression, Suicide | ClinicalTrials.gov |
| Interventions | 5ARI | ClinicalTrials.gov |
| Lead sponsor | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | ClinicalTrials.gov |
| Results first posted | 2018-02-05 | ClinicalTrials.gov |
| Results on ClinicalTrials.gov | https://clinicaltrials.gov/study/NCT02876757?tab=results | ClinicalTrials.gov |
Source 4
| Field | Value | Source |
|---|---|---|
| Release | trial-comparisons-2026-03-23-0.1.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57 | ClinicalTrials.gov |
| AACT copy | 2026-03-23 | ClinicalTrials.gov |
| Tables read | outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet | ClinicalTrials.gov |
Release trial-comparisons-2026-03-23-0.1.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.