Comparison · NCT02927067-e42d0c7e
Valganciclovir 900 mg BID vs Maribavir 400 mg BID: Number of Participants With Treatment-Emergent Adverse Events During the On-Treatment Period
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Valganciclovir 900 mg BID vs Maribavir 400 mg BID: Number of Participants With Treatment-Emergent Adverse Events During the On-Treatment Period. Trial comparisons, record NCT02927067-e42d0c7e. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02927067-e42d0c7e
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.982 | 0.958 | 0.992 | wilson | |
| Risk in group 2 | 0.982 | 0.958 | 0.992 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0000668 | -0.0259 | 0.0261 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1 | 0.977 | 1.02 | log | |
| Odds ratio, group 1 over group 2 | 1 | 0.287 | 3.51 | log | |
| Number needed to treat, for one more participant with the outcome on Valganciclovir 900 mg BID than on Maribavir 400 mg BID | 15,000 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Valganciclovir 900 mg BID | Participants received 900 mg of valganciclovir along with a placebo matched to maribavir, BID orally for 8 weeks. Valganciclovir dose was allowed to be adjusted to 450 mg BID or 450 mg QD based on renal function impairment assessed at baseline or development of neutropenia during the study. | 269 | 274 | OG000 |
| Group 2 | Maribavir 400 mg BID | Participants received 400 mg of maribavir along with a placebo matched to valganciclovir, BID orally for 8 weeks. | 268 | 273 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants With Treatment-Emergent Adverse Events During the On-Treatment Period
- Description
An adverse event (AE) is any untoward medical occurrence in a clinical investigation participants administered a pharmaceutical product and that does not necessarily have a causal relationship with this treatment. An AE that has a start date on or after the first dose of study treatment, or that has a start date before the date of first dose of study treatment but increases in severity after the first dose of study treatment, will be considered a treatment-emergent AE (TEAE).
- Time frame
- From the start of the study treatment to 7 days after the last dose of study treatment (up to approximately Week 9)
- Population
- Safety set included all participants who took at least 1 dose of study treatment.
Source ClinicalTrials.gov
Trial
- Title
- A Study of Maribavir Compared to Valganciclovir to Treat Cytomegalovirus Infections in People Who Have Received Stem Cell Transplants
- NCT number
- NCT02927067
- Phases
- PHASE3
- Conditions
- Cytomegalovirus (CMV)
- Interventions
- Maribavir, Valganciclovir, Placebo
- Lead sponsor
- Shire
- Results first posted
- 2023-03-03
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02927067?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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