Comparison · NCT02930018-e12ca8eb
Nerinetide, 2.6 mg/kg vs Placebo: Number of Subjects With mRS Score of 0 to 2
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Nerinetide, 2.6 mg/kg vs Placebo: Number of Subjects With mRS Score of 0 to 2. Trial comparisons, record NCT02930018-e12ca8eb. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02930018-e12ca8eb
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.614 | 0.572 | 0.654 | wilson | |
| Risk in group 2 | 0.592 | 0.55 | 0.632 | wilson | |
| Risk difference, group 1 minus group 2 | 0.0221 | -0.0355 | 0.0795 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.04 | 0.943 | 1.14 | log | |
| Odds ratio, group 1 over group 2 | 1.1 | 0.862 | 1.4 | log | |
| Number needed to treat, for one more participant with the outcome on Nerinetide, 2.6 mg/kg than on Placebo | 45.2 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Nerinetide, 2.6 mg/kg | Single intravenous infusion of nerinetide over 10 ± 1 minutes | 337 | 549 | OG001 |
| Group 2 | Placebo | Drug vehicle only~Placebo: Placebo Comparator: Placebo | 329 | 556 | OG000 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Subjects With mRS Score of 0 to 2
- Description
Overall number of subjects experiencing a favorable functional outcome 90 days post-randomization, defined as 0 to 2 on the mRS.~The modified Rankin Scale (mRS) is a valid and reliable clinician-reported measure of global disability that has been widely applied for evaluating recovery from stroke. It is a scale used to measure functional recovery (the degree of disability or dependence in daily activities) of people who have suffered a stroke. mRS scores range from 0 (best outcome) to 6 (worst outcome), with 0 indicating no residual symptoms; 5 indicating bedbound, requiring constant care; and 6 indicating death.
- Time frame
- 90 Days
- Population
- Intent-to-Treat Population
Source ClinicalTrials.gov
Trial
- Title
- Safety and Efficacy of Nerinetide (NA-1) in Subjects Undergoing Endovascular Thrombectomy for Stroke
- NCT number
- NCT02930018
- Phases
- PHASE3
- Conditions
- Stroke, Acute
- Interventions
- Nerinetide (NA-1), 2.6 mg/kg, Placebo
- Lead sponsor
- NoNO Inc.
- Results first posted
- 2020-12-14
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02930018?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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