Comparison · NCT02932475-1ce85a1c
Metformin vs Placebo: Number of Participants With Composite Adverse Neonatal Outcome
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Metformin vs Placebo: Number of Participants With Composite Adverse Neonatal Outcome. Trial comparisons, record NCT02932475-1ce85a1c. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT02932475-1ce85a1c
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.697 | 0.649 | 0.741 | wilson | |
| Risk in group 2 | 0.725 | 0.678 | 0.767 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0282 | -0.092 | 0.0358 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.961 | 0.878 | 1.05 | log | |
| Odds ratio, group 1 over group 2 | 0.872 | 0.638 | 1.19 | log | |
| Number needed to treat, for one fewer participant with the outcome on Metformin than on Placebo | 35.4 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Metformin | Metformin 1000 mg twice a day | 269 | 386 | OG000 |
| Group 2 | Placebo | Placebo, identical to Metformin. Delivered to match active drug | 277 | 382 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Participants With Composite Adverse Neonatal Outcome
- Description
Participants with one or more of the following:~* capillary blood glucose level of \< 30 mg/dL or capillary blood glucose requiring medical treatment, or~* Birth trauma (umbilical cord artery pH \< 7.0 or shoulder dystocia with brachial plexus injury), or~* Hyperbilirubinemia requiring phototherapy, or~* Deliver \< 37 weeks' gestation, or~* Miscarry, are stillborn, experience a neonatal demise, or~* Large for gestational age infant (birth weight \> 90th percentile for gestational age), or~* Small for gestational age infant (birth weight \< 10th percentile for gestational age) or low birth weight (\< 2500 gm)
- Time frame
- An average of 48 hours for term infants and 30 days for preterm infants
- Population
- Modified intent to treat population of all participants who took at least one dose of study agent and had primary outcome data available.
Source ClinicalTrials.gov
Trial
- Title
- Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy (MOMPOD)
- NCT number
- NCT02932475
- Phases
- PHASE3
- Conditions
- Diabetes, Pregnancy
- Interventions
- Metformin, Placebo
- Lead sponsor
- University of North Carolina, Chapel Hill
- Results first posted
- 2023-05-24
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT02932475?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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