Comparison · NCT03007394-c5c5d324
Lorcaserin vs Placebo Oral Capsule: The Primary Endpoint is the Actual Number of Subjects That Successfully Achieve Abstinence From Cocaine During the Last Three Weeks of Treatment in the Pre-qualified for Primary Efficacy Endpoint (PPEE) Population
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Lorcaserin vs Placebo Oral Capsule: The Primary Endpoint is the Actual Number of Subjects That Successfully Achieve Abstinence From Cocaine During the Last Three Weeks of Treatment in the Pre-qualified for Primary Efficacy Endpoint (PPEE) Population. Trial comparisons, record NCT03007394-c5c5d324. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03007394-c5c5d324
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.00847 | 0.0015 | 0.0464 | wilson | |
| Risk in group 2 | 0.0323 | 0.0126 | 0.08 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0238 | -0.072 | 0.019 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.263 | 0.0298 | 2.32 | log | |
| Odds ratio, group 1 over group 2 | 0.256 | 0.0282 | 2.33 | log | |
| Number needed to treat, for one fewer participant with the outcome on Lorcaserin than on Placebo Oral Capsule | 42 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Lorcaserin | 10 mg capsule by mouth, twice a day, for 13 weeks~Lorcaserin: Lorcaserin Capsule | 1 | 118 | OG000 |
| Group 2 | Placebo Oral Capsule | 10 mg placebo capsule, twice a day, for 13 weeks~Placebo Oral Capsule: sugar pill to mimic lorcaserin 10mg capsule | 4 | 124 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
The Primary Endpoint is the Actual Number of Subjects That Successfully Achieve Abstinence From Cocaine During the Last Three Weeks of Treatment in the Pre-qualified for Primary Efficacy Endpoint (PPEE) Population
- Description
Self-report data indicating no cocaine use on each day of the 3-week period, at least one benzoylecgonine (BE) assay result for a urine sample collect within the 3-weeks period and BE assay results are negative for all urine samples collected during the 3-week period.
- Time frame
- Treatment weeks 11 - 13
- Population
Source ClinicalTrials.gov
Trial
- Title
- Lorcaserin in the Treatment of Cocaine Use Disorder
- NCT number
- NCT03007394
- Phases
- PHASE2
- Conditions
- Cocaine-Related Disorders
- Interventions
- Lorcaserin, Placebo Oral Capsule
- Lead sponsor
- National Institute on Drug Abuse (NIDA)
- Results first posted
- 2020-06-19
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03007394?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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