Comparison · NCT03007394-sae
Lorcaserin vs Placebo Oral Capsule: serious adverse events
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Lorcaserin vs Placebo Oral Capsule: serious adverse events. Trial comparisons, record NCT03007394-sae. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03007394-sae
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0339 | 0.0133 | 0.0839 | wilson | |
| Risk in group 2 | 0.0484 | 0.0224 | 0.102 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0145 | -0.0715 | 0.0419 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.701 | 0.203 | 2.42 | log | |
| Odds ratio, group 1 over group 2 | 0.69 | 0.19 | 2.51 | log | |
| Number needed to treat, for one fewer participant with a serious adverse event on Lorcaserin than on Placebo Oral Capsule | 69 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Group 2 names the comparator: placebo.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Lorcaserin | 10 mg capsule by mouth, twice a day, for 13 weeks~Lorcaserin: Lorcaserin Capsule | 4 | 118 | EG000 |
| Group 2 | Placebo Oral Capsule | 10 mg placebo capsule, twice a day, for 13 weeks~Placebo Oral Capsule: sugar pill to mimic lorcaserin 10mg capsule | 6 | 124 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, serious adverse events
- Time frame
- Adverse event data were collected every week during treatment and through study follow-up, a 13-week treatment phase with a 4-week follow-up period.
Source ClinicalTrials.gov
Trial
- Title
- Lorcaserin in the Treatment of Cocaine Use Disorder
- NCT number
- NCT03007394
- Phases
- PHASE2
- Conditions
- Cocaine-Related Disorders
- Interventions
- Lorcaserin, Placebo Oral Capsule
- Lead sponsor
- National Institute on Drug Abuse (NIDA)
- Results first posted
- 2020-06-19
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03007394?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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