Comparison · NCT03029208-8ac44d32
Daprodustat vs Darbepoetin Alfa: Number of Participants Permanently Stopping Randomized Treatment Due to Meeting Rescue Criteria
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
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ConductScience Library. Daprodustat vs Darbepoetin Alfa: Number of Participants Permanently Stopping Randomized Treatment Due to Meeting Rescue Criteria. Trial comparisons, record NCT03029208-8ac44d32. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03029208-8ac44d32
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.0318 | 0.0137 | 0.0724 | wilson | |
| Risk in group 2 | 0.0323 | 0.0139 | 0.0733 | wilson | |
| Risk difference, group 1 minus group 2 | -0.000411 | -0.0453 | 0.0441 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.987 | 0.292 | 3.34 | log | |
| Odds ratio, group 1 over group 2 | 0.987 | 0.28 | 3.48 | log | |
| Number needed to treat, for one fewer participant with the outcome on Daprodustat than on Darbepoetin Alfa | 2,430 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Daprodustat | Participants received daprodustat film-coated tablets with titrated dose levels ranging from 1, 2, 4, 6, 8, 10, 12, 16, and 24 milligrams (mg) orally once daily for up to 52 weeks. Study treatment was dose-titrated to achieve and maintain hemoglobin (Hgb) in the target range (10 to 11 grams per deciliter \[g/dL\]). | 5 | 157 | OG000 |
| Group 2 | Darbepoetin Alfa | Participants received darbepoetin alfa as prefilled syringes (PFS) for subcutaneous or intravenous (IV) injection with 4-weekly total dose levels ranging from 20, 30, 40, 60, 80, 120, 160, 200, 300 and 400 microgram (mcg) for 52 weeks. Study treatment was dose-titrated to achieve and maintain Hgb in the target range (10 to 11 g/dL). | 5 | 155 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- SECONDARY
- Title
- Number of Participants Permanently Stopping Randomized Treatment Due to Meeting Rescue Criteria
- Description
- Number of participants permanently stopping randomized treatment due to meeting rescue criteria has been presented.
- Time frame
- Up to Week 52
- Population
- ITT Population.
Source ClinicalTrials.gov
Trial
- Title
- Anemia Studies in Chronic Kidney Disease (CKD): Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor (PHI) Daprodustat-in Incident Dialysis (ASCEND-ID)
- NCT number
- NCT03029208
- Phases
- PHASE3
- Conditions
- Anaemia
- Interventions
- Daprodustat, Darbepoetin alfa, Iron therapy
- Lead sponsor
- GlaxoSmithKline
- Results first posted
- 2021-10-20
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03029208?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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