Comparison · NCT03049618-deaths
Head and Neck Cancer Cohort vs Non-Small Cell Lung Cancer Cohort: deaths from any cause
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Head and Neck Cancer Cohort vs Non-Small Cell Lung Cancer Cohort: deaths from any cause. Trial comparisons, record NCT03049618-deaths. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03049618-deaths
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.48 | 0.3 | 0.665 | wilson | |
| Risk in group 2 | 0.353 | 0.173 | 0.587 | wilson | |
| Risk difference, group 1 minus group 2 | 0.127 | -0.168 | 0.385 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 1.36 | 0.635 | 2.91 | log | |
| Odds ratio, group 1 over group 2 | 1.69 | 0.477 | 6.01 | log | |
| Number needed to harm, for one more death from any cause on Head and Neck Cancer Cohort than on Non-Small Cell Lung Cancer Cohort | 7.87 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Head and Neck Cancer Cohort | Patients receive pembrolizumab IV over 30 minutes on day 1 and recombinant EphB4-HSA fusion protein IV over 30 minutes on days 1, 8, and 15. Courses repeat every 3 weeks for up to 24 months in the absence of disease progression or unacceptable toxicity.~Laboratory Biomarker Analysis: Correlative studies~Pembrolizumab: Given IV~Recombinant EphB4-HSA Fusion Protein: Given IV | 12 | 25 | EG000 |
| Group 2 | Non-Small Cell Lung Cancer Cohort | Patients receive pembrolizumab IV over 30 minutes on day 1 and recombinant EphB4-HSA fusion protein IV over 30 minutes on days 1, 8, and 15. Courses repeat every 3 weeks for up to 24 months in the absence of disease progression or unacceptable toxicity.~Laboratory Biomarker Analysis: Correlative studies~Pembrolizumab: Given IV~Recombinant EphB4-HSA Fusion Protein: Given IV | 6 | 17 | EG001 |
Source ClinicalTrials.gov
Harm
- What it counts
- Total, all-cause mortality
- Time frame
- Up to 41 months
Source ClinicalTrials.gov
Trial
- Title
- Recombinant EphB4-HSA Fusion Protein and Pembrolizumab, MK-3475
- NCT number
- NCT03049618
- Phases
- PHASE2
- Conditions
ALK Gene Mutation, BRAF Gene Mutation, EGFR Gene Mutation, Head and Neck Squamous Cell Carcinoma, Metastatic Head and Neck Carcinoma, Recurrent Head and Neck Carcinoma, Recurrent Non-Small Cell Lung Carcinoma, ROS1 Gene Mutation, Stage III Non-Small Cell Lung Cancer, Stage IIIA Non-Small Cell Lung Cancer, Stage IIIB Non-Small Cell Lung Cancer, Stage IV Non-Small Cell Lung Cancer
- Interventions
- Laboratory Biomarker Analysis, Pembrolizumab, Recombinant EphB4-HSA Fusion Protein
- Lead sponsor
- University of Southern California
- Results first posted
- 2025-10-22
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03049618?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
For software
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GET https://conductscience.org/api/comparisons/v1/NCT03049618-deaths