Comparison · NCT03106870-dab816d8
Oral Metformin and Insulin vs Insulin Therapy Only: Number of Participants With Glycemic Control Over Period From 20 Weeks to 36 Weeks Gestation
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
2 sourcestrial-comparisons-2026-03-23-0.1.0
Cite this record
ConductScience Library. Oral Metformin and Insulin vs Insulin Therapy Only: Number of Participants With Glycemic Control Over Period From 20 Weeks to 36 Weeks Gestation. Trial comparisons, record NCT03106870-dab816d8. Release trial-comparisons-2026-03-23-0.1.0, 23 Mar 2026. https://conductscience.org/library/comparisons/NCT03106870-dab816d8
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Measures6
Calculated by ConductScience from the counts the trial posted to ClinicalTrials.gov.
| Measure | Value | 95% interval, lower | 95% interval, upper | Method | Note |
|---|---|---|---|---|---|
| Risk in group 1 | 0.774 | 0.602 | 0.886 | wilson | |
| Risk in group 2 | 0.871 | 0.711 | 0.949 | wilson | |
| Risk difference, group 1 minus group 2 | -0.0968 | -0.286 | 0.098 | newcombe hybrid score | |
| Risk ratio, group 1 over group 2 | 0.889 | 0.704 | 1.12 | log | |
| Odds ratio, group 1 over group 2 | 0.508 | 0.132 | 1.95 | log | |
| Number needed to treat, for one fewer participant with the outcome on Oral Metformin and Insulin than on Insulin Therapy Only | 10.3 | from the risk difference interval | the interval includes no difference |
Source ClinicalTrials.gov
Groups2
Neither group, or both, names a comparator, so the groups keep ClinicalTrials.gov's order.
| Group | Title | Description | With the outcome | Analysed | ClinicalTrials.gov code |
|---|---|---|---|---|---|
| Group 1 | Oral Metformin and Insulin | Intervention 'Insulin Mixtard' and Intervention 'metformin' had included~Insulin Mixtard: Insulin dose:~* 0.7 IU/Kg (at the second trimester of pregnancy).~* 0.8 IU/Kg (at the third trimester of pregnancy). Insulin dose was raised at a rate of 1 IU for every 10 mg/dl higher than the target blood glucose concentration.~Metformin: Oral metformin at a dose of 1500 mg divided into three doses, were taken with meals, in addition to insulin.~If the target blood glucose concentrations were not attained, the dose of metformin was raised to 2000 mg per day. | 24 | 31 | OG000 |
| Group 2 | Insulin Therapy Only | Intervention 'Insulin Mixtard' had included~Insulin Mixtard: Insulin dose:~* 0.7 IU/Kg (at the second trimester of pregnancy).~* 0.8 IU/Kg (at the third trimester of pregnancy). Insulin dose was raised at a rate of 1 IU for every 10 mg/dl higher than the target blood glucose concentration. | 27 | 31 | OG001 |
Source ClinicalTrials.gov
Outcome
- Type
- PRIMARY
- Title
- Number of Participants With Glycemic Control Over Period From 20 Weeks to 36 Weeks Gestation
- Description
Fasting and two-hours postprandial blood glucose every 48 hours, till reaching the target blood glucose concentrations:~60 - 95 mg/dl and \< 120 mg/dl (for fasting and two-hour postprandial status, respectively) If patient reached blood glucose concentrations, she considered as controlled Diabetes Mellitus If patient did not reach blood glucose concentrations, she considered as uncontrolled Diabetes Mellitus
- Time frame
- from 20 weeks to 36 weeks gestation
- Population
Source ClinicalTrials.gov
Trial
- Title
- Adding Metformin to Insulin in Controlling Pregestational and Gestational Diabetes Mellitus
- NCT number
- NCT03106870
- Phases
- NA
- Conditions
- Gestational Diabetes Mellitus in Pregnancy
- Interventions
- Insulin Mixtard, Metformin
- Lead sponsor
- Ain Shams University
- Results first posted
- 2017-06-14
- Results on ClinicalTrials.gov
- https://clinicaltrials.gov/study/NCT03106870?tab=results
Source ClinicalTrials.gov
Source
- Release
- trial-comparisons-2026-03-23-0.1.0
- Release manifest SHA-256
- f66225897fbf258b57ea10bdacfd0347d3cdfda93f7f5685234b7e06ea36fa57
- AACT copy
- 2026-03-23
- Tables read
- outcome_counts.parquet, outcome_measurements.parquet, outcomes.parquet, reported_event_totals.parquet, reported_events.parquet, result_groups.parquet, studies.parquet, ctgov_trial.parquet
Source ClinicalTrials.gov
Sources 2
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions. The measures are ConductScience's calculation from them.
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